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FAUC-365

Catalog No. T21667 CAS 474432-66-1

Synonyms: FAUC-365 Benzo[b]thiophene-2-carboxylic acid {4-[4-(2,3-dichloro- phenyl)-piperazin-1-yl]-butyl}-amide, FAUC-365 Benzo[b]thiophene-2-carboxylic acid {4-[4-(2,3-dichloro- phenyl)-piperazin-1-yl]-butyl}-amide

FAUC-365 is a D3 dopamine receptor agonist.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

FAUC-365, CAS 474432-66-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 48.00
5 mg	In stock	$ 113.00
10 mg	In stock	$ 172.00
25 mg	In stock	$ 339.00
50 mg	In stock	$ 538.00
100 mg	In stock	$ 778.00
500 mg	In stock	$ 1,620.00
1 mL * 10 mM (in DMSO)	In stock	$ 125.00

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Purity: 98.09%

Biological Description

Chemical Properties

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Description	FAUC-365 is a D3 dopamine receptor agonist.
Targets&IC50	5-HT:0.50 nM(Ki)
In vitro	As a dichloro derivative, FAUC-365 revealed D3 affinities that were comparable to its methoxy-substituted analogs, however, the selectivities of FAUC-365 against 5HT-1A, 5-HT2, and R1 were substantially higher, which was demonstrated by the extraordinary selectivity ratios of 17600, 7200, 5200, and 680 over D1, D2long, D2short, and D4, respectively, were determined for FAUC-365 with Ki of 0.50 nM. In addition, the benzothiophene analog FAUC 346 and its oxa analog showed partial agonist character with EC50 values at 0.36 and 1.5 nM, respectively [1].

Synonyms	FAUC-365 Benzo[b]thiophene-2-carboxylic acid {4-[4-(2,3-dichloro- phenyl)-piperazin-1-yl]-butyl}-amide, FAUC-365 Benzo[b]thiophene-2-carboxylic acid {4-[4-(2,3-dichloro- phenyl)-piperazin-1-yl]-butyl}-amide
Molecular Weight	462.44
Formula	C23H25Cl2N3OS
CAS No.	474432-66-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: insoluble

DMSO: 50 mg/mL (108.12 mM)

EtOH: insoluble

References and Literature

1. Bettinetti L, Schlotter K, Hübner H, Gmeiner P. Interactive SAR studies:rational discovery of super-potent and highly selective dopamine D3 receptor antagonists and partial agonists. J Med Chem. 2002 Oct 10;45(21):4594-7.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Neurodegenerative Disease Compound Library GPCR Compound Library Neuronal Signaling Compound Library Neurotransmitter Receptor Compound Library Bioactive Compound Library Anti-Parkinson's Disease Compound Library Bioactive Compounds Library Max

Related Products

Related compounds with same targets

UCSF924 Promethazine Dopamine hydrochloride Ropinirole hydrochloride FAUC 346 Pramipexole dihydrochloride hydrate U 99194 maleate Quetiapine

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Keywords

FAUC-365 474432-66-1 GPCR/G Protein Neuroscience Dopamine Receptor inhibit Parkinson's disease FAUC365 D3 receptor Dopamine Inhibitor schizophrenia SPET FAUC 365 FAUC-365 Benzo[b]thiophene-2-carboxylic acid {4-[4-(2,3-dichloro- phenyl)-piperazin-1-yl]-butyl}-amide Radioligand FAUC-365 Benzo[b]thiophene-2-carboxylic acid {4-[4-(2,3-dichloro- phenyl)-piperazin-1-yl]-butyl}-amide inhibitor

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