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FR-188582

Catalog No. T15345 CAS 189699-82-9

FR-188582 is a highly selective cyclooxygenase (COX)-2 inhibitor (IC50: 17 nM).

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FR-188582, CAS 189699-82-9

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,670.00
50 mg	6-8 weeks	$ 2,180.00
100 mg	6-8 weeks	$ 2,800.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description	FR-188582 is a highly selective cyclooxygenase (COX)-2 inhibitor (IC50: 17 nM).
Targets&IC50	COX-2:17 nM
In vitro	FR-188582 inhibits COX-2 (IC50: 17 nM), in a recombinant human COX enzyme activity. The inhibition of prostaglandin (PG) E2 formation by FR188582 is over 6000 times more selective for COX-2 than COX-1.
In vivo	FR-188582 (0.01-3.2 mg/kg, p.o.) reverses paw edema in adjuvant arthritic rats and displays a therapeutic effect in a dose-dependent manner. For adjuvant-injected paws and adjuvant-uninjected paws, the ED50s values (95% C.L.) are 0.074 (0.00021-0.53) and 0.063 (0.0039-0.31) mg/kg , respectively. The anti-inflammatory effect of FR-188582 is threefold more potent than that of Indomethacin. For adjuvant-injected paws and adjuvant-uninjected paws, the ED50s values (95% C.L.) are 0.24 (0.047-1.8) and 0.20 (0.021-0.79) mg/kg, respectively.

Molecular Weight	332.8
Formula	C16H13ClN2O2S
CAS No.	189699-82-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Ochi T, et al. The anti-inflammatory effect of FR188582, a highly selective inhibitor of cyclooxygenase-2, with an ulcerogenic sparing effect in rats. Jpn J Pharmacol. 2001 Feb;85(2):175-82.

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Keywords

FR-188582 189699-82-9 Immunology/Inflammation Neuroscience COX FR 188582 FR188582 inhibitor inhibit

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