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FTBMT

Catalog No. T15352 CAS 1358575-02-6

FTBMT is a selective GPR52 agonist (EC50: 75 nM) and it also has antipsychotic and procognitive properties.

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FTBMT, CAS 1358575-02-6

Pack Size	Availability	Price/USD
1 mg	In stock	$ 50.00
5 mg	In stock	$ 86.00
10 mg	In stock	$ 148.00
25 mg	In stock	$ 329.00
50 mg	In stock	$ 581.00
100 mg	In stock	$ 829.00
1 mL * 10 mM (in DMSO)	In stock	$ 94.00

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Purity: 99.12%

Biological Description

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Description	FTBMT is a selective GPR52 agonist (EC50: 75 nM) and it also has antipsychotic and procognitive properties.
Targets&IC50	GPR52:75 nM(EC50)
In vitro	In CHO cells expressing human, mouse, or rat GPR52, FTBMT (0.1-10 μM) improves intracellular cAMP levels (pEC50s of 7.03, 6.85, and 6.87, respectively)[2].
In vivo	In rats, FTBMT (3 or 10 mg/kg, 48 hours) improves recognition and spatial working memory. FTBMT (30 mg/kg, 90 minutes) shows antipsychotic-like activity without causing catalepsy in mice[2]

Molecular Weight	392.35
Formula	C19H16F4N4O
CAS No.	1358575-02-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45 mg/mL (114.69 mM), Sonification is recommended.

H2O: < 0.1 mg/mL (insoluble)

References and Literature

1. Tokumaru K, et al. Design, synthesis, and pharmacological evaluation of 4-azolyl-benzamide derivatives as novel GPR52 agonists. Bioorg Med Chem. 2017 Jun 15;25(12):3098-3115. 2. Nishiyama K, et al. FTBMT, a Novel and Selective GPR52 Agonist, Demonstrates Antipsychotic-Like and Procognitive Effects in Rodents, Revealing a Potential Therapeutic Agent for Schizophrenia. J Pharmacol Exp Ther. 2017 Nov;363(2):253-264.

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Bioactive Compounds Library Max Endocrinology-Hormone Compound Library Bioactive Compound Library

Related Products

Related compounds with same targets

MS21570 Tyrphostin A25 GPCR agonist-2 AZD1981 Urotensin II (114-124), human acetate GSK1292263 CRTh2 antagonist 2 4-CMTB

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Keywords

FTBMT 1358575-02-6 Endocrinology/Hormones GPCR/G Protein GPR inhibit Inhibitor inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.