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Favipiravir

Catalog No. T6833 CAS 259793-96-9

Synonyms: T-705, 6-Fluoro-3-oxo-3,4-dihydropyrazine-2-carboxamide

Favipiravir (T-705) (T-705), an effective and selective RNA-dependent RNA polymerase inhibitor, are applied to treat influenza virus infections.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Favipiravir, CAS 259793-96-9

Pack Size	Availability	Price/USD
5 mg	In stock	$ 41.00
10 mg	In stock	$ 57.00
50 mg	In stock	$ 82.00
100 mg	In stock	$ 124.00
500 mg	In stock	$ 315.00
1 mL * 10 mM (in DMSO)	In stock	$ 45.00

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Purity: 100%

Purity: 99.30%

Purity: 98.16%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Favipiravir (T-705) (T-705), an effective and selective RNA-dependent RNA polymerase inhibitor, are applied to treat influenza virus infections.
Targets&IC50	RdRP:341 nM.
In vitro	Favipiravir shows anti-influenza virus activities with IC50 ranged from 0.013 to 0.48 μg/ml for the influenza A viruses, from 0.039 to 0.089 μg/ml for the influenza B viruses, and from 0.030 to 0.057 μg/ml for the influenza C viruses. In mammalian cell lines (MDCK cells, Vero cells, HEL cells, A549 cells, HeLa cells, and HEp-2 cells), Favipiravir shows no cytotoxicity at concentrations up to 1,000 μg/ml. [1] In MDCK cells inoculated with seasonal influenza A (H1N1) viruses, Favipiravir induces lethal mutagenesis. [2]
In vivo	In influenza virus-infected mice, Favipiravir (200 mg/kg/day, p.o.) protects the mice from death from influenza virus infection. [1] In mice experimentally infected with Ebola virus, Favipiravir efficiently blocks viral production, reaching an antiviral effectiveness of 95% and 99.6% at 2 and 6days after initiation of treatment, respectively. [3]
Cell Research	The cytotoxicity of T-705 is evaluated by an assay with XTT. XTT is converted to aqueous formazan by an enzyme in MDCK cells, Vero cells, HEL cells, A549 cells, HeLa cells, and HEp-2 cells. The compounds are diluted to the appropriate concentrations (volume, 100 μl) with test medium (EMEM containing 10% FCS) in 96-well culture plates in which each well contains a concentration of 2 × 103 cells/100 μL. The test plates are incubated for 3 days at 37°C in 100% humidity and 5% CO2. After 3 days, 50 μl of the XTT reagent (1 mg/ml in FCS-free EMEM containing 5 mM phenazine methosulfate) is added, and the reaction product is assayed by measurement of the absorbance at 450 nm with a microplate reader. Cytotoxicity is expressed as the 50% cell-inhibitory concentration (CC50).(Only for Reference)

Synonyms	T-705, 6-Fluoro-3-oxo-3,4-dihydropyrazine-2-carboxamide
Molecular Weight	157.1
Formula	C5H4FN3O2
CAS No.	259793-96-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 12 mg/mL(76.4 mM)

H2O: 5 mg/mL (31.82 mM)

DMSO: 29 mg/mL (184.6 mM)

References and Literature

1. Furuta Y, et al. Antimicrob Agents Chemother. 2002, 46(4), 977-981. 2. Baranovich T, et al. J Virol. 2013, 87(7), 3741-3751. 3. Madelain V, et al. Antiviral Res. 2015, 123, 70-77. 4. WEI X U, Shuai X, Jing P, et al. The antihistamine drugs carbinoxamine maleate and chlorpheniramine maleate exhibit potent antiviral activity against a broad spectrum of influenza viruses[J]. Frontiers in Microbiology. 2018 Nov 6;9:2643. 5. Qiu M, Li Z, Chen Y, et al. Tolcapone Potently Inhibits Seminal Amyloid Fibrils Formation and Blocks Entry of Ebola Pseudoviruses. Frontiers in Microbiology. 2020, 11: 504.

Citations

1. Nicholson M W, Huang C Y, Wang J Y, et al. Cardio-and Neurotoxicity of Selected Anti-COVID-19 Drugs. Pharmaceuticals. 2022, 15(6): 765 2. Qiu M, Li Z, Chen Y, et al. Tolcapone Potently Inhibits Seminal Amyloid Fibrils Formation and Blocks Entry of Ebola Pseudoviruses. Frontiers in Microbiology. 2020, 11: 504 3. WEI X U, Shuai X, Jing P, et al. The antihistamine drugs carbinoxamine maleate and chlorpheniramine maleate exhibit potent antiviral activity against a broad spectrum of influenza viruses. Frontiers in Microbiology. 2018 Nov 6;9:2643 4. Zhang J, He M, Xie Q, et al.Predicting In Vitro and In Vivo Anti-SARS-CoV-2 Activities of Antivirals by Intracellular Bioavailability and Biochemical Activity.ACS Omega.2022 5. Westover J B, Jung K H, Alkan C, et al.Modeling Heartland virus disease in mice and therapeutic intervention with 4′-fluorouridine.Journal of Virology.2024: e00132-24.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Anti-Cancer Approved Drug Library Inhibitor Library Drug Repurposing Compound Library FDA-Approved & Pharmacopeia Drug Library Approved Drug Library Anti-COVID-19 Compound Library Bioactive Compound Library Clinical Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Favipiravir 259793-96-9 Cell Cycle/Checkpoint DNA Damage/DNA Repair Microbiology/Virology Others SARS-CoV DNA/RNA Synthesis Influenza Virus inhibit T705 SARS coronavirus T-705 Inhibitor T 705 6-Fluoro-3-oxo-3,4-dihydropyrazine-2-carboxamide inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.