Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Fenobam shows inverse agonist activity which blocks the mGlu5 receptor basal activity(IC50: 84 nM). Fenobam has anxiolytic activity. Fenobam is a selective and non-competitive mGluR5 antagonist acting at an allosteric modulatory site (Kd values are 54 and 31 nM for rat and human recombinant mGlu5 receptors, respectively).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 48.00 | |
5 mg | In stock | $ 97.00 | |
10 mg | In stock | $ 172.00 | |
25 mg | In stock | $ 288.00 | |
50 mg | In stock | $ 433.00 | |
100 mg | In stock | $ 628.00 | |
500 mg | In stock | $ 1,290.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 146.00 |
Description | Fenobam shows inverse agonist activity which blocks the mGlu5 receptor basal activity(IC50: 84 nM). Fenobam has anxiolytic activity. Fenobam is a selective and non-competitive mGluR5 antagonist acting at an allosteric modulatory site (Kd values are 54 and 31 nM for rat and human recombinant mGlu5 receptors, respectively). |
Targets&IC50 | mGluR5 (rat):54 nM (kd), mGluR5 (human):31 nM (kd) |
In vivo | Fenobam sulfate (30-60 mg/kg; p.o.) inhibited cocaine self-administration significantly [3]. |
Molecular Weight | 266.68 |
Formula | C11H11ClN4O2 |
CAS No. | 57653-26-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/ml (206.24 mM)
You can also refer to dose conversion for different animals. More
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Fenobam 57653-26-6 Neuroscience GluR anxiolytic brain-penetrant mGluR nonbenzodiazepine Inhibitor addiction inhibit cocaine Metabotropic glutamate receptors inhibitor