Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ferulenol, a sesquiterpene prenylated coumarin derivative, exhibits potent antimycobacterial activity and haemorrhagic action. This compound selectively targets succinate ubiquinone reductase within the ubiquinone cycle as its specific mode of inhibition.
Description | Ferulenol, a sesquiterpene prenylated coumarin derivative, exhibits potent antimycobacterial activity and haemorrhagic action. This compound selectively targets succinate ubiquinone reductase within the ubiquinone cycle as its specific mode of inhibition. |
In vitro | At low concentrations, ferulenol suppresses ATP synthesis by targeting adenine nucleotide translocase (ANT), affecting its function without restricting mitochondrial respiration. As concentrations increase, it also reduces oxygen consumption. Specifically, ferulenol targets succinate ubiquinone reductase (SQR) within complex II, inhibiting its function without impacting the succinate dehydrogenase activity. This inhibition occurs in a concentration-dependent manner, with ferulenol's efficacy comparable to that of thenoyltrifluoroacetone (TTFA). Furthermore, ferulenol disrupts the oxidative phosphorylation process through its interactions with ANT and complex II of the respiratory chain, showcasing its multifaceted inhibitory effects on cellular energy processes. |
Molecular Weight | 366.49 |
Formula | C24H30O3 |
CAS No. | 6805-34-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Ferulenol 6805-34-1 Others inhibitor inhibit