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Firuglipel

Catalog No. T15283 CAS 1371591-51-3

Firuglipel is an orally available and selective agonist of GPR119.

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Firuglipel, CAS 1371591-51-3

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Firuglipel is an orally available and selective agonist of GPR119.
In vitro	Firuglipel increases intracellular cAMP in a concentration-dependent manner in rat, human, and mouse GPR119-expressing Chinese hamster ovary (CHO)-K1 cells (EC50: 51.5, 98.4, and 108.1 nM, respectively). Firuglipel has no effect on intracellular cAMP in pcDNA3.1/CHO-K1 cells.
In vivo	Firuglipel (1-30 mg/kg) upregulates glucagon-like peptide-1. It also enhances glucose-dependent insulin secretion and improves glucose homeostasis in type 2 diabetic rats.

Molecular Weight	467.49
Formula	C25H26FN3O5
CAS No.	1371591-51-3

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Matsumoto K, et al. DS-8500a, an Orally Available G Protein-Coupled Receptor 119 Agonist, Upregulates Glucagon-Like Peptide-1 and Enhances Glucose-Dependent Insulin Secretion and Improves Glucose Homeostasis in Type 2 Diabetic Rats. J Pharmacol Exp Ther. 2018 Dec;367(3):509-517.

Related Products

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MK-7246 CAY10471 Racemate P2Y2R/GPR17 antagonist 1 SNAP 94847 Latanoprost acid GW-1100 Firuglipel AM-4668

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Firuglipel 1371591-51-3 G蛋白偶联受体内分泌与激素 GPR Inhibitor inhibitor inhibit

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