Home Tools

Flavoxate hydrochloride

Catalog No. T0703 CAS 3717-88-2

Synonyms: Flavoxate HCl, NSC-114649, DW61, Rec-7-0040

Flavoxate hydrochloride (DW61) , a muscarinic AChR antagonist, is used in the therapy of various urinary syndromes and as an antispasmodic.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Flavoxate hydrochloride Chemical Structure

Flavoxate hydrochloride, CAS 3717-88-2

Pack Size	Availability	Price/USD
25 mg	In stock	$ 30.00
50 mg	In stock	$ 43.00
100 mg	In stock	$ 58.00
200 mg	In stock	$ 63.00
1 g	In stock	$ 89.00

Bulk Inquiry

Select Batch

Purity: 99.64%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Flavoxate hydrochloride (DW61) , a muscarinic AChR antagonist, is used in the therapy of various urinary syndromes and as an antispasmodic.
Targets&IC50	mAChR:12.2 μM
In vitro	Without altering basal bladder pressure in rats, Flavoxate (3 mg/kg) can halt efferent nerve activity and associated bladder contractions for approximately 10 minutes. At the same dosage, administered intravenously, Flavoxate abolishes rhythmic bladder contractions, with maximum intervals of voiding contractions reaching 7.20 minutes. In rats, at a higher concentration (10 mg/kg), Flavoxate suppresses both the initial rapid-rise contraction phase (Phase 1) and the sustained contraction phase (Phase 2) to an equivalent degree. Furthermore, at this concentration, Flavoxate eliminates bladder contractions without altering contraction amplitude. Intracerebroventricular (ICV) injections of Flavoxate ranging from 50 to 200 mg or intrathecal (IT) injections of 100 to 200 mg dose-dependently abolish rhythmic bladder contractions within 5 to 15 minutes post-administration.
In vivo	Flavoxate inhibits cAMP formation in a concentration-dependent manner (0.01~10 μM) from membranes extracted from the rat cerebral cortex and striatum, an effect completely negated by pertussis toxin pretreatment. At concentrations greater than 10 μM, Flavoxate suppresses detrusor muscle contraction induced by acetylcholine, with a pD value of 4.55, and also inhibits contractions induced by Ca2+, with a pIC50 value of 4.92. Flavoxate concentration-dependently reduces K+-induced contractions of human bladder. It can displace [3H]nitrendipine at Ca2+ channel binding sites, with an IC50 of 254 μM. Flavoxate also concentration- and voltage-dependently inhibits the peak amplitude of inward Ba2+ currents sensitive to the voltage-dependent nifedipine in human detrusor smooth muscle cells (Ki: 10 μM), and inhibits the same Ba2+ currents at both 30°C (Ki = 5.1 mM) and 37°C (Ki = 4.6 mM).

Synonyms	Flavoxate HCl, NSC-114649, DW61, Rec-7-0040
Molecular Weight	427.92
Formula	C24H26ClNO4
CAS No.	3717-88-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 2.5 mM

References and Literature

1. Dansette PM, et al. Exp Toxicol Pathol, 2000, 52(2), 145-148. 2. Kimura Y, et al. Int J Urol, 1996, 3(3), 218-227. 3. Oka M, et al. Brain Res, 1996, 727(1-2), 91-98. 4. Tomoda T, et al. Br J Pharmacol, 2005, 146(1), 25-32. 5. Tomoda T, et al. Naunyn Schmiedebergs Arch Pharmacol, 2007, 376(3), 195-203.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library Inhibitor Library Drug Repurposing Compound Library Membrane Protein-targeted Compound Library FDA-Approved Drug Library Anti-Aging Compound Library Drug-induced Liver Injury (DILI) Compound Library FDA-Approved & Pharmacopeia Drug Library Neurotransmitter Receptor Compound Library Anti-Alzheimer's Disease Compound Library

Related Products

Related compounds with same targets

9-Ethyladenine Dipivefrin hydrochloride DREADD agonist 21 Conodurine Carbetapentane citrate Gallamine triethiodide Sch412348 mAChr-in-1

Dose Conversion

You can also refer to dose conversion for different animals. More

In vivo Formulation Calculator (Clear solution)

Step One: Enter information below

Dosage

mg/kg

Average weight of animals

Dosing volume per animal

Number of animals

Step Two: Enter the in vivo formulation

% DMSO+

% +

% Tween 80+

% ddH₂O

%DMSO+

Calculate Reset

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

Calculator

Molarity Calculator

Dilution Calculator

Reconstitution Calculation

Molecular Weight Calculator

Mass

Concentration

Volume

Molecular Weight

Molarity Calculator allows you to calculate the

Mass of a compound required to prepare a solution of known volume and concentration
Volume of solution required to dissolve a compound of known mass to a desired concentration
Concentration of a solution resulting from a known mass of compound in a specific volume

See Example

An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
Enter 10 into the Volume box and select the correct unit (milliliter)
Press calculate
The answer of 19.713 mg appears in the Mass box

Concentration (Start)

Volume (Start)

Concentration (End)

Volume (End)

Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

See Example

An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
Enter 20 into the Volume (final) box and select the correct unit (milliliter)
Press calculate
The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

Calculate the volume of solvent required to reconstitute your vial.

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial.
Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Molecule Formula

Molecular Weight g/mol

Enter the chemical formula of a compound to calculate its molar mass and elemental composition

Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

bottom

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Flavoxate hydrochloride 3717-88-2 Neuroscience AChR lower urinary tract infections Phosphodiesterase Calcium Channel mAChR anesthetic overactive bladder Flavoxate HCl Ca2+ channels DW-61 Ca channels Inhibitor NSC-114649 antispasmodic DW61 inhibit NSC114649 muscarinic NSC 114649 DW 61 Muscarinic acetylcholine receptor Flavoxate Hydrochloride Rec-7-0040 Phosphodiesterase (PDE) Flavoxate inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.