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Flumatinib mesylate

Catalog No. T7861 CAS 895519-91-2

Synonyms: HHGV678 mesylate

Flumatinib mesylate (HHGV678 mesylate) is a selective inhibitor of c-Abl, PDGFRβ and c-Kit, effectively overcomes drug resistance of certain KIT mutants.

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Flumatinib mesylate, CAS 895519-91-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 57.00
5 mg	In stock	$ 139.00
10 mg	In stock	$ 207.00
25 mg	In stock	$ 350.00
50 mg	In stock	$ 525.00
100 mg	In stock	$ 758.00
500 mg	In stock	$ 1,580.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.82%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Flumatinib mesylate (HHGV678 mesylate) is a selective inhibitor of c-Abl, PDGFRβ and c-Kit, effectively overcomes drug resistance of certain KIT mutants.

In vitro

In vivo study consistently suggested that flumatinib had superior efficacy compared with imatinib or sunitinib against 32D cells with the secondary mutation Y823D.?Molecular modeling of flumatinib docked to the KIT kinase domain suggested a special mechanism underlying the capability of flumatinib to overcome the drug-resistance conferred by activation loop mutations.?These findings suggest that flumatinib could be a promising therapeutic agent against GISTs resistant to both imatinib and sunitinib because of secondary mutations in the activation loop[1].

Synonyms	HHGV678 mesylate
Molecular Weight	658.69
Formula	C30H33F3N8O4S
CAS No.	895519-91-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 50 mg/mL (75.91 mM)

DMSO: 50 mg/mL (75.91 mM)

References and Literature

1. Zhao J , Quan H , Xu Y , et al. Flumatinib, a selective inhibitor of BCR-ABL/PDGFR/KIT, effectively overcomes drug resistance of certain KIT mutants[J]. Cancer Science, 2014, 105(1):117-125. 2. Yang Y , Liu K , Zhong D , et al. Simultaneous determination of flumatinib and its two major metabolites in plasma of chronic myelogenous leukemia patients by liquid chromatography–tandem mass spectrometry[J]. Journal of Chromatography B Analytical Technologies in the Biomedical & Life Sciences, 2012, 895-896(none):25-30.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Approved Drug Library Anti-Cancer Active Compound Library FDA-Approved Kinase Inhibitor Library Inhibitor Library Kinase Inhibitor Library Drug Repurposing Compound Library Tyrosine Kinase Inhibitor Library Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Bioactive Compounds Library Max

Related Products

Related compounds with same targets

AG957 Vamotinib Imatinib GNF-7 BGG463 GNF-5 Berbamine dihydrochloride NVP-BAW2881

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Flumatinib mesylate 895519-91-2 Angiogenesis Cytoskeletal Signaling Tyrosine Kinase/Adaptors c-Kit PDGFR Bcr-Abl HHGV-678 PDGFRβ HHGV678 c-Abl Platelet-derived growth factor receptor Flumatinib Mesylate HHGV 678 HHGV-678 Mesylate SCFR Flumatinib CD117 HHGV 678 Mesylate HHGV678 mesylate Inhibitor HHGV678 Mesylate inhibit inhibitor

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