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Fluphenazine decanoate

Catalog No. T7943 CAS 5002-47-1

Fluphenazine decanoate is dopamine D2 receptor blocke,and is a long-acting phenothiazine neuroleptic that used to treat schizophrenia.

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Fluphenazine decanoate Chemical Structure

Fluphenazine decanoate, CAS 5002-47-1

Pack Size	Availability	Price/USD
5 mg	In stock	$ 35.00
10 mg	In stock	$ 59.00
25 mg	In stock	$ 77.00
50 mg	In stock	$ 97.00
100 mg	In stock	$ 178.00
200 mg	In stock	$ 268.00
500 mg	In stock	$ 453.00
1 mL * 10 mM (in DMSO)	In stock	$ 47.00

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Purity: 100%

Biological Description

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Description

Fluphenazine decanoate is dopamine D2 receptor blocke,and is a long-acting phenothiazine neuroleptic that used to treat schizophrenia.

In vivo

Six female Persian onagers (Equus hemionus onager) were treated with fluphenazine decanoate (FD;?0.1?mg/kg IM) or saline control in a random crossover design study.?Urinary cortisol, progesterone, estrogen metabolites and behavior were monitored, and follicular dynamics were examined using ultrasonography until ovulation.?Onagers demonstrated significantly lower cortisol concentrations (P?=?0.03) when treated with FD (6.61?±?3.26?ng/mg creatinine) compared to saline (9.73?±?3.19?ng/mg creatinine).?Overall, there were no differences in peak estrogen (P?=?0.51) or progesterone (P?=?0.38) concentrations between the two groups, and all animals ovulated within the expected time frame following FD treatment.?However, some onagers exhibited only minor reductions in cortisol secretion and one treated female demonstrated a suppressed luteal progesterone peak, indicating a possible reproductive cost to FD administration[1].

Molecular Weight	591.77
Formula	C32H44F3N3O2S
CAS No.	5002-47-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 125 mg/mL (211.23 mM), Sonication is recommended.

References and Literature

1. Wagman J D , Wolfe B A , Schook M W . The effect of fluphenazine decanoate on glucocorticoid production, reproductive cyclicity, and the behavioral stress response in the Persian onager (\r, Equus hemionus onager\r, )[J]. Zoo Biology, 2015, 34(6):525-534. 2. Falloon I R , Watt D C , Shepherd M . A Comparative Controlled Trial of Pimozide and Fluphenazine Decanoate in the Continuation Therapy of Schizophrenia[J]. Psychological Medicine, 1978, 8(1):59-70.

Related compound libraries

This product is contained In the following compound libraries：

Membrane Protein-targeted Compound Library Anti-Cancer Approved Drug Library Anti-Cancer Clinical Compound Library Drug Repurposing Compound Library GPCR Compound Library Anti-Cancer Drug Library Anti-Neurodegenerative Disease Compound Library NO PAINS Compound Library Bioactive Compound Library Human Metabolite Library

Related Products

Related compounds with same targets

Cariprazine hydrochloride Melitracen hydrochloride ABT-724 Pramipexole dihydrochloride Brexpiprazole Benserazide hydrochloride Remoxipride hydrochloride cis-(Z)-Flupentixol dihydrochloride

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Keywords

Fluphenazine decanoate 5002-47-1 GPCR/G Protein Neuroscience Dopamine Receptor hypothalamic tyrosine hydroxylase levels gonadotropin suppression phenothiazine T. gondii Inhibitor reproductive mouth movements hyperprolactinemia neuroleptic inhibit dopamine-D2 human tardive dyskinesia antifertility serum prolactin schizophrenia long-acting jaw tremor vacuous chewing mouth movement inhibitor

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