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Flupirtine maleate

Catalog No. T6504 CAS 75507-68-5

Synonyms: Katadolon maleate

Flupirtine maleate (Katadolon maleate), a centrally acting non-opioid analgesia, is the salt form of Flupirtine. It is an NMDA receptor antagonist , and also a specific neuronal potassium channel opener.

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Flupirtine maleate, CAS 75507-68-5

Pack Size	Availability	Price/USD
10 mg	In stock	$ 45.00
50 mg	In stock	$ 56.00
100 mg	In stock	$ 77.00
200 mg	In stock	$ 123.00
500 mg	In stock	$ 296.00
1 mL * 10 mM (in DMSO)	In stock	$ 48.00

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Purity: 99.9%

Purity: 98.99%

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Storage & Solubility Information

Description

Cell Research

For measurement of viability and generation of reactive oxygen intermediates, PC12 cells are seeded in 24- or 96-well plates coated with poly-L-lysine at 105 cells/mL. Drugs are dissolved in PBS (pH 7.4), or ethanol and filtered sterile. At the end of each experiment cells are trypsinized and pelleted together with cells of the culture supernatant. After staining for 10 min with 0.2% Trypan blue solution live (unstained) and dead (Trypan blue positive) cells are counted in a hemocytometer chamber. In addition, cellular viability is evaluated by the reduction of MTT to formazan. After 2 hours incubation with MTT (0.5 mg/ml) at 37 °C, cells are lysed in DMSO. Extinction at 570 nm is determined on a plate photometer. For staining of surviving adherent cells, plates are incubated for 10 min with 0.5% crystalviolet dissolved in 20% methanol. Plates are rinsed with water and stained cells are lysed in 50% ethanol, 0.1 M sodiumcitrate before determining extinction at 550 nm. (Only for Reference)

Synonyms	Katadolon maleate
Molecular Weight	420.39
Formula	C15H17FN4O2·C4H4O4
CAS No.	75507-68-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 42 mg/mL (100 mM)

Ethanol: 4.2 mg/mL (10 mM)

References and Literature

1. Perovic S, et al. Eur J Pharmacol, 1994, 288(1), 27-33. 2. Rupalla K, et al. Eur J Pharmacol, 1995, 294(2-3), 469-473 3. Müller WE, et al. J Neurochem, 1997, 68(6), 2371-237 4. Seyfried J, et al. Eur J Pharmacol, 2000, 400(2-3):155-166. 5. Dörr J, et al. J Neuroimmunol, 2005, 167(1-2), 204-209.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Anti-Cancer Drug Library Membrane Protein-targeted Compound Library Anti-Neurodegenerative Disease Compound Library EMA Approved Drug Library Anti-Cancer Approved Drug Library Anti-Cancer Clinical Compound Library Inhibitor Library Drug Repurposing Compound Library Antidepressant Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Flupirtine maleate 75507-68-5 Membrane transporter/Ion channel Neuroscience Potassium Channel NMDAR iGluR centrally acting brain,?penetrant KcsA Flupirtine Neuroprotective Inhibitor inhibit Ionotropic glutamate receptors stroke non-opioid Katadolon Maleate Katadolon maleate Flupirtine Maleate analgesic inhibitor

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