Home Tools

Cart

Flutamide

Catalog No. T0489 CAS 13311-84-7

Synonyms: SCH 13521

Flutamide (SCH 13521) is an antiandrogen with about the same potency as cyproterone in rodent and canine species.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Flutamide, CAS 13311-84-7

Pack Size	Availability	Price/USD
200 mg	In stock	$ 30.00
500 mg	In stock	$ 46.00
1 g	In stock	$ 48.00
5 g	Inquiry	$ 92.00
1 mL * 10 mM (in DMSO)	In stock	$ 51.00

Bulk Inquiry

Select Batch

Purity: 99.92%

Purity: 99.6%

Purity: 99.41%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Flutamide (SCH 13521) is an antiandrogen with about the same potency as cyproterone in rodent and canine species.
Targets&IC50	Androgen receptor:55 nM(Ki)
In vitro	Flutamide significantly reduced the prostate weight in rats from 319 mg to 245 mg. Co-administration of Flutamide with a luteinizing hormone-releasing hormone (LHRH) agonist compounded side effects, further decreasing prostate weight to 101 mg and markedly diminishing prostatic ornithine decarboxylase (ODC) activity.
In vivo	The concurrent use of Flutamide and leuprorelin can be employed in the treatment of prostate cancer. The active metabolite of Flutamide, Flutamide-OH, binds directly to the androgen receptors in the anterior pituitary of rats (Ki=55 nM). Flutamide does not affect the proliferation of androgen-sensitive clones in the Shionogi SC-115 mouse mammary carcinoma cells when cultured, displaying only antiandrogenic effects without any androgenic activity.
Kinase Assay	Androgen Receptor Assay: Aliquots of 100 μl cytosol are incubated at 0-4°C for 18 h with 100 μl of the indicated saturating concentration of [3H]T in the presence or absence of increasing concentrations of nonlabeled T, DHT, flutamide (FLU) or flutamide-OH (FLU-OH). At the end of the incubation, free and bound T are separated by the addition of 200 μl dextran-coated charcoal (1 % charcoal, 0.1% dextran T-70, 0.1% gelatin, 1.5 mM EDTA and 50 mM Tris (pH 7.4)) for 15 min before centrifugation at 2300 × g for another 15 min at 0-4°C. Aliquots (350 μl) of the supernatant are transferred to scintillation vials with 10 ml of an aqueous counting solution before counting in a Beckman LS 330 counter.
Cell Research	Effect of flutamide on the growth of an androgen-sensitive clone (SEM-l) of mouse mammary carcinoma Shionogi cells in culture. The cells are incubated up to 40 days in medium (MEM + 2% dextran-coated charcoal extracted fetal calf serum) containing the compounds at a concentration of 1 μM. Media are changed every second day.(Only for Reference)

Synonyms	SCH 13521
Molecular Weight	276.21
Formula	C11H11F3N2O3
CAS No.	13311-84-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 51 mg/mL (184.6 mM)

Ethanol: 51 mg/mL (184.6 mM)

References and Literature

1. Simard J, et al. Mol Cell Endocrinol, 1986, 44(3), 261-270. 2. Luthy IA, et al. J Steroid Biochem, 1988, 31(5), 845-852. 3. Crawford ED, et al. N Engl J Med, 1989, 321(7), 419-424. 4. Marchetti B, et al. J Steroid Biochem, 1988, 29(6), 691-698.

Citations

1. Yang R, Wang X, Wang J, et al. Insights into the sex-dependent reproductive toxicity of 2-ethylhexyl diphenyl phosphate on zebrafish (Danio rerio). Environment International. 2022, 158: 106928.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Anti-Cancer Clinical Compound Library Drug Repurposing Compound Library Anti-Cancer Approved Drug Library Anti-Cancer Drug Library Drug-Fragment Library Drug-induced Liver Injury (DILI) Compound Library Bioactive Compound Library FDA-Approved Drug Library Anti-Cancer Compound Library

Related Products

Related compounds with same targets

Apalutamide ACP-105 2,2,5,7,8-Pentamethyl-6-Chromanol Clascoterone LGD-2226 RU 58841 ARD-1676 Androgen receptor degrader-1

Dose Conversion

You can also refer to dose conversion for different animals. More

In vivo Formulation Calculator (Clear solution)

Step One: Enter information below

Dosage

mg/kg

Average weight of animals

Dosing volume per animal

Number of animals

Step Two: Enter the in vivo formulation

% DMSO+

% +

% Tween 80+

% ddH₂O

%DMSO+

Calculate Reset

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

Calculator

Molarity Calculator

Dilution Calculator

Reconstitution Calculation

Molecular Weight Calculator

Mass

Concentration

Volume

Molecular Weight

Molarity Calculator allows you to calculate the

Mass of a compound required to prepare a solution of known volume and concentration
Volume of solution required to dissolve a compound of known mass to a desired concentration
Concentration of a solution resulting from a known mass of compound in a specific volume

See Example

An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
Enter 10 into the Volume box and select the correct unit (milliliter)
Press calculate
The answer of 19.713 mg appears in the Mass box

Concentration (Start)

Volume (Start)

Concentration (End)

Volume (End)

Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

See Example

An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
Enter 20 into the Volume (final) box and select the correct unit (milliliter)
Press calculate
The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

Calculate the volume of solvent required to reconstitute your vial.

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial.
Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Molecule Formula

Molecular Weight g/mol

Enter the chemical formula of a compound to calculate its molar mass and elemental composition

Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

bottom

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Flutamide 13311-84-7 Endocrinology/Hormones Androgen Receptor Inhibitor SCH-13521 SCH 13521 inhibit SCH13521 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.