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Foliglurax monohydrochloride

Catalog No. T11311   CAS 2133294-96-7
Synonyms: PXT002331 (monohydrochloride)

Foliglurax monohydrochloride Antiparkinsonian effect. is a highly selective and potent, brain-penetrant metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) , with an EC50 of 79 nM.

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Foliglurax monohydrochloride Chemical Structure
Foliglurax monohydrochloride, CAS 2133294-96-7
Pack Size Availability Price/USD Quantity
5 mg 6-8 weeks $ 427.00
25 mg 6-8 weeks $ 1,330.00
50 mg 6-8 weeks $ 1,740.00
100 mg 6-8 weeks $ 2,500.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Foliglurax monohydrochloride Antiparkinsonian effect. is a highly selective and potent, brain-penetrant metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) , with an EC50 of 79 nM.
Targets&IC50 mGlu4:79 nM (EC50)
In vitro Foliglurax, might revolutionize the field of mGlu4 receptor drug targeting in CNS disorders.a highly selective and potent mGlu4 receptor PAM with a marked brain-penetrance feature.
Synonyms PXT002331 (monohydrochloride)
Molecular Weight 457.97
Formula C23H24ClN3O3S
CAS No. 2133294-96-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 5 mg/mL (10.92 mM), sonification is recommended.

TargetMolReferences and Literature

1. Charvin D, et al. Discovery, Structure-Activity Relationship, and Antiparkinsonian Effect of a Potent and Brain-Penetrant Chemical Series of Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4. J Med Chem. 2017 Oct 26;60(20):8515-8537. 2. Volpi C, et al. Opportunities and challenges in drug discovery targeting metabotropic glutamate receptor 4. Expert Opin Drug Discov. 2018 May;13(5):411-423.

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Keywords

Foliglurax monohydrochloride 2133294-96-7 Others Foliglurax PXT002331 PXT-002331 Foliglurax Monohydrochloride PXT002331 (monohydrochloride) PXT 002331 inhibitor inhibit

 

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