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Fosamprenavir Calcium Salt

Catalog No. T8238   CAS 226700-81-8
Synonyms: Diallyl Trisulfide, GW433908G

Fosamprenavir Calcium Salt (GW433908G) (GW433908G) is a phosphate ester prodrug of the antiretroviral protease inhibitor Amprenavir, with improved solubility. Fosamprenavir Calcium Salt has Anti-HIV infection.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Fosamprenavir Calcium Salt Chemical Structure
Fosamprenavir Calcium Salt, CAS 226700-81-8
Pack Size Availability Price/USD Quantity
1 mg In stock $ 55.00
2 mg In stock $ 79.00
5 mg In stock $ 139.00
10 mg In stock $ 228.00
25 mg In stock $ 366.00
50 mg In stock $ 495.00
100 mg In stock $ 719.00
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Purity: 99.59%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Fosamprenavir Calcium Salt (GW433908G) (GW433908G) is a phosphate ester prodrug of the antiretroviral protease inhibitor Amprenavir, with improved solubility. Fosamprenavir Calcium Salt has Anti-HIV infection.
In vivo Oral gavage of DATS significantly retarded growth of PC-3 xenografts in athymic mice without causing weight loss. For instance, 20 days after starting therapy, the average tumor volume in control mice was approximately 3-fold higher compared with DATS-treated mice. Tumors from DATS-treated mice exhibited a markedly higher count of apoptotic bodies compared with control tumors. Consistent with the results in cultured PC-3 cells, the DATS-mediated suppression of PC-3 xenograft growth correlated with induction of proapoptotic proteins Bax and Bak. Although DATS treatment inhibited migration of cultured PC-3 cells in association with down-regulation of vascular endothelial growth factor receptor-2 protein, formation of new blood vessels was comparable in tumors of control and DATS-treated mice as judged by CD31 immunostaining[1].
Animal Research DATS was given orally (6 micromoL, thrice weekly) to male athymic mice s.c. implanted with PC-3 cells. Tumor sections from control and DATS-treated mice were examined for apoptotic bodies by terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling assay. Protein levels of apoptosis and cell cycle regulating proteins in tumor tissues of control and DATS-treated mice were determined by immunoblotting. The effect of DATS treatment on in vivo angiogenesis was determined by immunohistochemical analysis of CD31 in tumors[1].
Synonyms Diallyl Trisulfide, GW433908G
Molecular Weight 623.67
Formula C25H34CaN3O9PS
CAS No. 226700-81-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 1.8 mg/mL (2.89 mM), sonification/heating is recommended.

H2O: 0.25 mg/mL (0.40 mM), sonification/heating is recommended.

TargetMolReferences and Literature

1. Falcoz C, et al. Pharmacokinetics of GW433908, a prodrug of amprenavir, in healthy male volunteers. J Clin Pharmacol. 2002 Aug;42(8):887-98. 2. Michael P , Silvia S . Dietary Bioactive Diallyl Trisulfide in Cancer Prevention and Treatment[J]. International Journal of Molecular Sciences, 2017, 18(8):1645-. 3. Xiao D , Lew K L , Kim Y A , et al. Diallyl Trisulfide Suppresses Growth of PC-3 Human Prostate Cancer Xenograft In vivo in Association with Bax and Bak Induction[J]. Clinical Cancer Research, 2006, 12(22):6836-6843.

Related compound libraries

This product is contained In the following compound libraries:
FDA-Approved Drug Library Anti-Viral Compound Library Clinical Compound Library Bioactive Compounds Library Max FDA-Approved & Pharmacopeia Drug Library Bioactive Compound Library Approved Drug Library Covalent Inhibitor Library Drug Repurposing Compound Library Inhibitor Library

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Keywords

Fosamprenavir Calcium Salt 226700-81-8 Microbiology/Virology Proteases/Proteasome HIV Protease Human immunodeficiency virus HIV Inhibitor Diallyl Diallyl Trisulfide GW433908G inhibit inhibitor

 

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