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Fosmanogepix

Catalog No. T11314   CAS 2091769-17-2
Synonyms: APX001, E1211

Fosmanogepix (APX001) is a first-in-class, orally available broad-spectrum antifungal agent. It acts as an N-phosphonooxymethyl prodrug that undergoes rapid and complete metabolism by systemic alkaline phosphatases. This metabolism leads to the formation of the active moiety, APX001A. Fosmanogepix (APX001), with its ability to target the highly conserved Gwt1 fungal enzyme, holds great potential for the development of treatments against invasive fungal infections.

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Fosmanogepix Chemical Structure
Fosmanogepix, CAS 2091769-17-2
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Fosmanogepix (APX001) is a first-in-class, orally available broad-spectrum antifungal agent. It acts as an N-phosphonooxymethyl prodrug that undergoes rapid and complete metabolism by systemic alkaline phosphatases. This metabolism leads to the formation of the active moiety, APX001A. Fosmanogepix (APX001), with its ability to target the highly conserved Gwt1 fungal enzyme, holds great potential for the development of treatments against invasive fungal infections.
Synonyms APX001, E1211
Molecular Weight 468.4
Formula C22H21N4O6P
CAS No. 2091769-17-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 5 mg/mL (10.67 mM), ultrasonic and adjust pH to 4 with HCl

TargetMolReferences and Literature

1. Shaw KJ, et al. In Vitro and In Vivo Evaluation of APX001A/APX001 and Other Gwt1 Inhibitors against Cryptococcus. Antimicrob Agents Chemother. 2018 Jul 27;62(8). pii: e00523-18. 2. Gebremariam T, et al. APX001 Is Effective in the Treatment of Murine Invasive Pulmonary Aspergillosis. Antimicrob Agents Chemother. 2019 Jan 29;63(2). pii: e01713-18.

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Keywords

Fosmanogepix 2091769-17-2 Others APX 001 APX001 E-1211 E1211 E 1211 APX-001 inhibitor inhibit

 

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