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Fosmidomycin sodium salt

Catalog No. T11315   CAS 66508-37-0
Synonyms: FR-31564 sodium salt

Fosmidomycin sodium salt (FR-31564 sodium salt) is an anti-infective antibiotic with anti-malarial activity that inhibits both Gram-negative and Gram-positive bacteria.

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Fosmidomycin sodium salt Chemical Structure
Fosmidomycin sodium salt, CAS 66508-37-0
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Purity: 99.18%
Purity: 99.18%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Fosmidomycin sodium salt (FR-31564 sodium salt) is an anti-infective antibiotic with anti-malarial activity that inhibits both Gram-negative and Gram-positive bacteria.
In vitro FR-31564 is a novel phosphonic acid antibiotic that exhibits activity against most Gram-negative and Gram-positive bacteria, except for mucoid Pseudomonas aeruginosa and glucose non-fermenting Gram-negative rods (excluding Pseudomonas aeruginosa).[1][2][3].
In vivo After oral administration of 50 or 100 mg/kg of Fosmidomycin sodium salt, animals showed no parasites in their bodies, while treatment with 20 mg/kg resulted in a parasitemia rate of less than 1%. However, recurrence was observed when treatment was discontinued after 4 days. Complete cure was achieved in mice treated with 30 mg/kg of Fosmidomycin sodium salt 8 days.Animals apparently free of parasites are observed after intraperitoneal treatment[2].
Synonyms FR-31564 sodium salt
Molecular Weight 205.08
Formula C4H9NNaO5P
CAS No. 66508-37-0

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 20 mg/mL (97.52 mM), sonification is recommended.

TargetMolReferences and Literature

1. Kojo H, et al. FR-31564, a new phosphonic acid antibiotic: bacterial resistance and membrane permeability. J Antibiot (Tokyo). 1980 Jan;33(1):44-8. 2. Jomaa H, et al. Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs. Science. 1999 Sep 3;285(5433):1573-6. 3. Fernandes JF, et al. Fosmidomycin as an antimalarial drug: a meta-analysis of clinical trials. Future Microbiol. 2015;10(8):1375-90.

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Keywords

Fosmidomycin sodium salt 66508-37-0 Microbiology/Virology Antibiotic Parasite Fosmidomycin sodium FR31564 FR-31564 sodium salt FR-31564 FR 31564 inhibitor inhibit

 

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