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Fostemsavir Tris

Catalog No. T10570   CAS 864953-39-9
Synonyms: BMS-663068 Tris

Fostemsavir Tris (BMS-663068 Tris) is the prodrug of BMS-626529,is a oral, safe and effective inhibitor of HIV-1 attachment. It inhibits human immunodeficiency virus type 1 (HIV-1) infection by binding to gp120 and interfering with the attachment of virus to CD4+ T-cells.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Fostemsavir Tris Chemical Structure
Fostemsavir Tris, CAS 864953-39-9
Pack Size Availability Price/USD Quantity
1 mg In stock $ 60.00
2 mg In stock $ 87.00
5 mg In stock $ 147.00
10 mg In stock $ 218.00
25 mg In stock $ 369.00
50 mg In stock $ 543.00
100 mg In stock $ 776.00
1 mL * 10 mM (in DMSO) In stock $ 219.00
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Purity: 99.95%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Fostemsavir Tris (BMS-663068 Tris) is the prodrug of BMS-626529,is a oral, safe and effective inhibitor of HIV-1 attachment. It inhibits human immunodeficiency virus type 1 (HIV-1) infection by binding to gp120 and interfering with the attachment of virus to CD4+ T-cells.
In vivo BMS-663068 is the phosphonooxymethyl prodrug of BMS-626529, a novel small-molecule attachment inhibitor that targets HIV-1 gp120 and prevents its binding to CD4(+) T cells.The activity of BMS-626529 is virus dependent, due to heterogeneity within gp120.?BMS-626529 had half-maximal effective concentration (EC(50)) values of <10 nM against the vast majority of viral isolates;?however, susceptibility varied by >6 log(10), with half-maximal effective concentration values in the low pM range against the most susceptible viruses.?The in vitro antiviral activity of BMS-626529 was generally not associated with either tropism or subtype, with few exceptions.?Measurement of the binding affinity of BMS-626529 for purified gp120 suggests that a contributory factor to its inhibitory potency may be a relatively long dissociative half-life.?
Synonyms BMS-663068 Tris
Molecular Weight 704.62
Formula C29H37N8O11P
CAS No. 864953-39-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 125 mg/mL (177.40 mM), sonification is recommended.

H2O: 100 mg/mL (141.92 mM), sonification is recommended.

TargetMolReferences and Literature

1. Nowicka-Sans B, et al. In vitro antiviral characteristics of HIV-1 attachment inhibitor BMS-626529, the active component of the prodrug BMS-663068. Antimicrob Agents Chemother. 2012 Jul;56(7):3498-507.

Related compound libraries

This product is contained In the following compound libraries:
Drug Repurposing Compound Library FDA-Approved Drug Library FDA-Approved & Pharmacopeia Drug Library NO PAINS Compound Library Inhibitor Library Bioactive Compound Library Anti-Viral Compound Library Bioactive Compounds Library Max Target-Focused Phenotypic Screening Library Anti-Infection Compound Library

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Keywords

Fostemsavir Tris 864953-39-9 Microbiology/Virology Proteases/Proteasome HIV Protease Inhibitor BMS-663068 Tris inhibit BMS 663068 BMS663068 HIV Human immunodeficiency virus Fostemsavir BMS-663068 inhibitor

 

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