Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Fostemsavir Tris (BMS-663068 Tris) is the prodrug of BMS-626529,is a oral, safe and effective inhibitor of HIV-1 attachment. It inhibits human immunodeficiency virus type 1 (HIV-1) infection by binding to gp120 and interfering with the attachment of virus to CD4+ T-cells.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 60.00 | |
2 mg | In stock | $ 87.00 | |
5 mg | In stock | $ 147.00 | |
10 mg | In stock | $ 218.00 | |
25 mg | In stock | $ 369.00 | |
50 mg | In stock | $ 543.00 | |
100 mg | In stock | $ 776.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 219.00 |
Description | Fostemsavir Tris (BMS-663068 Tris) is the prodrug of BMS-626529,is a oral, safe and effective inhibitor of HIV-1 attachment. It inhibits human immunodeficiency virus type 1 (HIV-1) infection by binding to gp120 and interfering with the attachment of virus to CD4+ T-cells. |
In vivo |
BMS-663068 is the phosphonooxymethyl prodrug of BMS-626529, a novel small-molecule attachment inhibitor that targets HIV-1 gp120 and prevents its binding to CD4(+) T cells.The activity of BMS-626529 is virus dependent, due to heterogeneity within gp120.?BMS-626529 had half-maximal effective concentration (EC(50)) values of <10 nM against the vast majority of viral isolates;?however, susceptibility varied by >6 log(10), with half-maximal effective concentration values in the low pM range against the most susceptible viruses.?The in vitro antiviral activity of BMS-626529 was generally not associated with either tropism or subtype, with few exceptions.?Measurement of the binding affinity of BMS-626529 for purified gp120 suggests that a contributory factor to its inhibitory potency may be a relatively long dissociative half-life.? |
Synonyms | BMS-663068 Tris |
Molecular Weight | 704.62 |
Formula | C29H37N8O11P |
CAS No. | 864953-39-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 125 mg/mL (177.40 mM), sonification is recommended.
H2O: 100 mg/mL (141.92 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Fostemsavir Tris 864953-39-9 Microbiology/Virology Proteases/Proteasome HIV Protease Inhibitor BMS-663068 Tris inhibit BMS 663068 BMS663068 HIV Human immunodeficiency virus Fostemsavir BMS-663068 inhibitor