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Fumitremorgin C

Catalog No. T15355 CAS 118974-02-0

Synonyms: 12α-Fumitremorgin C

Fumitremorgin C (12α-Fumitremorgin C) is a mycotoxin and inhibits ABCG2/BRCP.

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Fumitremorgin C, CAS 118974-02-0

Pack Size	Availability	Price/USD	Quantity
250 μg	35 days	$ 530.00
1 mg	35 days	$ 1,360.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Fumitremorgin C (12α-Fumitremorgin C) is a mycotoxin and inhibits ABCG2/BRCP.

In vitro

Multidrug resistance (MDR) presents a significant challenge in cancer chemotherapy, but Fumitremorgin C has shown remarkable efficacy in counteracting this problem by increasing drug accumulation in multidrug-selected cell lines. Specifically, it enhances the effectiveness of doxorubicin, mitoxantrone, and topotecan by reversing mitoxantrone resistance up to 114-fold and doxorubicin resistance 3-fold in MCF-7/mtxR cells. Additionally, in S1M1-3.2 cells, Fumitremorgin C substantially boosts the toxicity of these drugs, demonstrating a 26-fold increase for doxorubicin, 93-fold for mitoxantrone, and 24-fold for topotecan. However, it does not mitigate drug resistance in cells with high levels of Pgp or MRP expression [1]. Notably, Fumitremorgin C virtually eliminates resistance mediated by BCRP in vitro, making it a valuable pharmacological tool for investigating the expression and molecular functionality of this transporter. Furthermore, it significantly raises the toxicity of mitoxantrone and topotecan in vector-transfected MCF-7 cells by 2.5–5.6 fold and reduces the IC50 of topotecan in BCRP-overexpressing cells to levels even lower than those in untreated vector-transfected cells [2].

Synonyms	12α-Fumitremorgin C
Molecular Weight	379.45
Formula	C22H25N3O3
CAS No.	118974-02-0

Storage

store at low temperature,keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (131.77 mM), Sonication is recommended.

References and Literature

1. Rabindran SK, et al. Reversal of a novel multidrug resistance mechanism in human colon carcinoma cells by fumitremorgin C. Cancer Res. 1998 Dec 15;58(24):5850-8. 2. Rabindran SK, et al. Fumitremorgin C reverses multidrug resistance in cells transfected with the breast cancer resistance protein. Cancer Res. 2000 Jan 1;60(1):47-50.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Fumitremorgin C 118974-02-0 Membrane transporter/Ion channel Microbiology/Virology Antibacterial Antibiotic ABC BCRP Breast cancer resistance protein ABCG2 12a-Fumitremorgin C Inhibitor inhibit 12α-Fumitremorgin C Bacterial 12alpha-Fumitremorgin C inhibitor

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