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Fusidic acid

Catalog No. T1160   CAS 6990-06-3
Synonyms: Fusidine

Fusidic acid (Fusidine) is an antibiotic isolated from the fermentation broth of Fusidium coccineum.

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Fusidic acid Chemical Structure
Fusidic acid, CAS 6990-06-3
Pack Size Availability Price/USD Quantity
100 mg In stock $ 41.00
1 mL * 10 mM (in DMSO) In stock $ 45.00
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Purity: 100%
Purity: 99.53%
Purity: 98.68%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Fusidic acid (Fusidine) is an antibiotic isolated from the fermentation broth of Fusidium coccineum.
Kinase Assay DHODase activity is measured by the DCIP colorimetric assay. This is a coupled assay in which oxidation of DHO and subsequent reduction of ubiquinone are stoichiometrically equivalent to the reduction of DCIP. Reduction of DCIP is accompanied by a loss of absorbance at 610 nm (ε=21500 M/cm). The assay is performed in a 96-well microtiter plate at ambient temperature (ca. 25°C). Stock solutions of 10 mM leflunomide and A771726 are prepared in dimethyl sulfoxide (DMSO) and these are diluted with reaction buffer (100 mM Tris and 0.1 % Triton X-100, pH 8.0) to prepare working stocks of the inhibitors at varying concentrations. For each reaction, the well contained 10 nM DHODase, 68 μM DCIP, 0.16 mg/mL gelatin, the stated concentration of ubiquinone, 10 μL of an inhibitor working stock to give the stated final concentration, and reaction buffer. After a 5-min equilibration period, the reaction is initiated by addition of DHO to the stated final concentrations. The total volume of reaction mixture for each assay is 150 μL, and the final DMSO concentration is ≤ 0.01% (v/v). The reaction progress is followed by recording the loss of absorbance at 610 nm over a 10-min period (during which the velocity remained linear). Velocities are reported as the change in absorbance at 610 nm per minute, and each reported value is the average of three replicates. In experiments where the DHO or ubiquinone concentration is varied, the other substrate is held constant at 200 μM. To determine the inhibitor potency of leflunomide and A771726, the effects of varying concentrations of the two compounds on the initial velocity of the DHODase reaction is measured over a concentration range of 0.01?1.0 μM. In these experiments the DHO and ubiquinone concentrations are held constant at 200 and 100 μM, respectively.
Synonyms Fusidine
Molecular Weight 516.71
Formula C31H48O6
CAS No. 6990-06-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 91 mg/mL(176.1 mM)

TargetMolReferences and Literature

1. Day PJ, et al. Biochemistry. 1995 May 16;34(19):6416-22.

TargetMolCitations

1. Zhang H, Liang B, Sang X, et al.Discovery of Potential Inhibitors of SARS-CoV-2 Main Protease by a Transfer Learning Method.Viruses.2023, 15(4): 891.

Related compound libraries

This product is contained In the following compound libraries:
Microbial Natural Product Library Immunology/Inflammation Compound Library Anti-infective Natural Product Library Bioactive Compounds Library Max Anti-Aging Compound Library Natural Product Library for HTS Anti-Bacterial Compound Library Inhibitor Library NO PAINS Compound Library Approved Drug Library

Related Products

Related compounds with same targets
Chlorhexidine dihydrochloride Ethionamide Chlorhexidine 2-Pyridinecarbohydrazide Isoniazid Fomepizole Chlorhexidine diacetate Fusidic acid sodium salt

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Keywords

Fusidic acid 6990-06-3 Microbiology/Virology Others oxidation-reduction CAT Antibiotic Antibacterial SQ16603 elongation inhibit Inhibitor Fusidate growth Bacterial Fusidine ribosome SQ 16603 SQ-16603 bacteriostatic steroids factor inhibitor

 

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