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Galnon TFA(475115-35-6(free base))

Catalog No. T8559

Galnon is a novel non-peptide galanin receptor agonist (GAL1 and GAL2 with Ki of 11.7 and 34.1 μM respectively).

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Galnon TFA(475115-35-6(free base)) Chemical Structure

Galnon TFA(475115-35-6(free base)), CAS N/A

Pack Size	Availability	Price/USD
1 mg	In stock	$ 133.00
2 mg	In stock	$ 197.00
5 mg	In stock	$ 298.00
10 mg	In stock	$ 453.00
25 mg	In stock	$ 747.00
50 mg	In stock	$ 1,050.00
100 mg	In stock	$ 1,420.00
500 mg	In stock	$ 2,830.00
1 mL * 10 mM (in DMSO)	In stock	$ 198.00

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Purity: 99.92%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Galnon is a novel non-peptide galanin receptor agonist (GAL1 and GAL2 with Ki of 11.7 and 34.1 μM respectively).
In vivo	Galnon stimulated insulin release potently in isolated Wistar rat islets; 100 microM of the compound increased the release 8.5 times (p<0.001) at 3.3 mM and 3.7 times (p<0.001) at 16.7 mM glucose. Also in islet perifusions, galnon augmented several-fold both acute and late phases of insulin response to glucose. Furthermore, galnon stimulated insulin release in GK rat islets. These effects were not inhibited by the presence of galanin or the galanin receptor antagonist M35. The stimulatory effects of galnon were partly inhibited by the PKA and PKC inhibitors, H-89 and calphostin C, respectively, at 16.7 but not 3.3 mM glucose. In both Wistar and GK rat islets, insulin release was stimulated by depolarization of 30 mM KCl, and 100 microM galnon further enhanced insulin release 1.5-2 times (p<0.05). Cytosolic calcium levels, determined by fura-2, were increased in parallel with insulin release, and the L-type Ca2+-channel blocker nimodipine suppressed insulin response to glucose and galnon[1].galnon, a GAL receptor agonist, may enhance osteoclastic bone resorption in OVX rats. Although galnon reduced bone volume, biomechanical testing revealed that bone of galnon-treated animals was mechanically superior per unit area. Taken together, galnon simultaneously improves the intrinsic quality of cortical bone whilst stimulating osteoclastic activity in the OVX rat model[2].
Animal Research	OVX rats were treated with either vehicle or galnon for 6 weeks via mini-osmotic pumps. Plasma osteocalcin concentrations, osseous cell gene expression, morphological and biomechanical properties of the skeleton were compared between the two groups[2]

Molecular Weight	792.84
Formula	C42H47F3N4O8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 25 mg/mL (269.28 mM)

References and Literature

1. Quynh N T T , Islam S M , Anders Florén, et al. Effects of galnon, a non-peptide galanin-receptor agonist, on insulin release from rat pancreatic islets[J]. Biochem Biophys Res Commun, 2005, 328(1):213-220. 2. Mcgowan H W , Schuijers J A , Grills B L , et al. Galnon, a galanin receptor agonist, improves intrinsic cortical bone tissue properties but exacerbates bone loss in an ovariectomised rat model[J]. Journal of musculoskeletal & neuronal interactions, 2014, 14(2):162-172.

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Bioactive Compound Library NO PAINS Compound Library Bioactive Compounds Library Max Neuronal Signaling Compound Library Neurotransmitter Receptor Compound Library

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Keywords

Galnon TFA(475115-35-6(free base)) GPCR/G Protein Neuroscience Neuropeptide Y Receptor GALNON TFA(475115-35-6(free base)) GALNON TFA(475115356(free base)) GALNON TFA(475115 35 6(free base)) inhibitor inhibit

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