Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GDC-0276 has the potential for the treatment of pain and to address shortcomings of existing pain medications, such as addiction and off-target side effects. GDC-0276 is a potent, selective, reversible and orally active NaV1.7 inhibitor with an IC50 value of 0.4 nM. GDC-0276 is well tolerated and exhibits a good pharmacokinetic profile.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,530.00 | |
50 mg | 6-8 weeks | $ 1,990.00 | |
100 mg | 6-8 weeks | $ 2,800.00 |
Description | GDC-0276 has the potential for the treatment of pain and to address shortcomings of existing pain medications, such as addiction and off-target side effects. GDC-0276 is a potent, selective, reversible and orally active NaV1.7 inhibitor with an IC50 value of 0.4 nM. GDC-0276 is well tolerated and exhibits a good pharmacokinetic profile. |
Targets&IC50 | Nav1.7 electrophysiology:0.4 nM |
In vivo | GDC-0276 is not detected in urine;?however, metabolites in urine were enriched in 14C with observed specific activities of 19.6 μCi/mg.e.GDC-0276 (oral adminstration; 0.5-5 mg/kg) shows enrichment of 14C with observed specific activities of 22.6 μCi/mg. |
Molecular Weight | 462.58 |
Formula | C24H31FN2O4S |
CAS No. | 1494581-70-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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GDC-0276 1494581-70-2 Others GDC0276 GDC 0276 inhibitor inhibit