Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GDC-0834 Racemate is the racemate form of GDC-0834, which is an effective and selective BTK inhibitor
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | 5 days | $ 98.00 | |
5 mg | 5 days | $ 214.00 | |
50 mg | 6-8 weeks | $ 723.00 | |
100 mg | 6-8 weeks | $ 996.00 |
Description | GDC-0834 Racemate is the racemate form of GDC-0834, which is an effective and selective BTK inhibitor |
In vitro | GDC-0834 inhibited BTK (IC50s: 5.9 and 6.4 nM in biochemical and cellular assays) and (IC50s: 1.1 and 5.6 μM in mouse and rat) [1]. |
In vivo | Administration of GDC-0834 (30-100 mg/kg) in a rat collagen-induced arthritis (CIA) model resulted in a dose-dependent decrease of ankle swelling and reduction of morphologic pathology [1]. GDC-0834 exhibited low clearance in PXB chimeric mice with humanized liver. GDC-0834 plasma concentrations in humans were below the limit of quantitation (<1 ng/ml) in most samples from the cohorts dosed orally at 35 and 105 mg [2]. |
Molecular Weight | 596.74 |
Formula | C33H36N6O3S |
CAS No. | 1133432-46-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 49 mg/mL (82.11 mM)
You can also refer to dose conversion for different animals. More
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GDC-0834 Racemate 1133432-46-8 Others GDC 0834 Racemate GDC0834 Racemate inhibitor inhibit