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GLP-1(7-36), amide acetate

Catalog No. TP1141 CAS 1119517-19-9

Synonyms: GLP-1(7-36) Acetate, Human GLP-1-(7-36)-amide Acetate

GLP-1(7-36) Acetate is a major intestinal hormone that stimulates glucose-induced insulin secretion from β cells.

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GLP-1(7-36), amide acetate Chemical Structure

GLP-1(7-36), amide acetate, CAS 1119517-19-9

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	GLP-1(7-36) Acetate is a major intestinal hormone that stimulates glucose-induced insulin secretion from β cells.
In vitro	Cells exposed to phorbol 12-myristate 13-acetate for 2 hours exhibited significantly enhanced GLP-1(7-36) levels compared to untreated controls. Similarly, glucose exposure augmented GLP-1 secretion in a dose-responsive manner. Fatty acids, including palmitic, oleic, linoleic, and linolenic acids, also elevated GLP-1 secretion dose-dependently, with unsaturated fatty acids (oleic, linoleic, and linolenic acids) proving more potent than saturated palmitic acid. Furthermore, treatment with CPE on NCI-H716 cells led to a dose-dependent increase in GLP-1 levels, with a notable 37% rise at 0.1% CPE concentration[1].
In vivo	Administering glucose via the stomach elevates active GLP-1(7-36) amide levels in portal blood within 10 minutes, showing a significant reduction at 30 minutes. Similarly, gastric TO administration also boosts active GLP-1 levels at 10 minutes, with levels returning to baseline at 60 minutes. Both glucose and TO independently enhance GLP-1 secretion in a dose-responsive manner, with their combined administration synergistically elevating peak GLP-1 concentrations. Mice treated with CPE exhibit increased active GLP-1 levels at 10 and 30 minutes compared to control mice. Additionally, CPE treatment results in slightly elevated levels of both active GLP-1 and insulin in portal blood post-glucose administration versus controls. Mice fed a high-fat diet, specifically C57BL/6J strain, exhibit hyperglycemia and diminished glucose tolerance[1].

Synonyms	GLP-1(7-36) Acetate, Human GLP-1-(7-36)-amide Acetate
Molecular Weight	N/A
Formula	C149H226N40O45.xC2H4O2
CAS No.	1119517-19-9

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 50 mg/mL (14.73 mM), Sonification is recommended.

References and Literature

1. Fujii Y et al. Ingestion of coffee polyphenols increases postprandial release of the active glucagon-like peptide-1(GLP-1(7-36)) amide in C57BL/6J mice. J Nutr Sci. 2015 Mar 3

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Keywords

GLP-1(7-36), amide acetate 1119517-19-9 GLP 1 Acetate GLP1 Acetate Human GLP-1-amide Acetate GLP1(736), amide acetate GLP-1, amide Acetate GLP-1(7-36) Acetate GLP-1 Acetate GLP 1(7 36), amide acetate Human GLP-1-(7-36)-amide Acetate inhibitor inhibit

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