Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GLPG0974 is an antagonist of FFA2/GPR43 with IC50 of 9 nM.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 51.00 | |
5 mg | In stock | $ 122.00 | |
10 mg | In stock | $ 197.00 | |
25 mg | In stock | $ 396.00 | |
50 mg | In stock | $ 589.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 128.00 |
Description | GLPG0974 is an antagonist of FFA2/GPR43 with IC50 of 9 nM. |
Targets&IC50 | GPR43:9 nM |
In vitro | GLPG0974 inhibits acetate-induced neutrophil migration strongly and inhibits CD11b activation-specific epitope [AE], a neutrophil-based pharmacodynamic marker, in a human whole blood assay[1]. |
In vivo | GLPG0974(5 and 30 mg/kg; oral) exhibits good pharmacokinetic properties in rat with a bioavailability of 47% and dose-dependently increases the plasma exposure[1]. |
Synonyms | GLPG-0974 |
Molecular Weight | 484.99 |
Formula | C25H25ClN2O4S |
CAS No. | 1391076-61-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 180 mg/mL (371.1 mM), Sonification is recommended.
You can also refer to dose conversion for different animals. More
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GLPG0974 1391076-61-1 Endocrinology/Hormones GPCR/G Protein GPR GLPG-0974 GLPG 0974 inhibitor inhibit