Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GNE-220 is a potent and selective inhibitor of MAP4K4 (IC50: 7 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 8-10 weeks | $ 1,970.00 | |
50 mg | 8-10 weeks | $ 2,580.00 | |
100 mg | 8-10 weeks | $ 3,400.00 |
Description | GNE-220 is a potent and selective inhibitor of MAP4K4 (IC50: 7 nM). |
Targets&IC50 | MAP4K5:9 nM, MAP4K4:7 nM, MAP4K6:1.1 μM |
In vitro | GNE-220 alters human umbilical vein endothelial cells (HUVEC) sprout morphology.?GNE-220 also reduces pERM+ retraction fibres in a dose-dependent manner.?GNE-220 also dose-dependently increased the number of active-INTβ1+ long focal adhesions (FAs).GNE-220 also inhibits a few other kinases with IC50s of 9 nM, 476 nM and 1.1 μM for MINK (MAP4K6), DMPK and KHS1 (MAP4K5), respectively. |
Molecular Weight | 438.53 |
Formula | C25H26N8 |
CAS No. | 1199590-75-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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GNE 220 1199590-75-4 Others GNE220 GNE-220 inhibitor inhibit