Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GNF362 is a selective and orally bioavailable inhibitor of inositol trisphosphate 3’ kinase B (Itpkb; IC50: 9 nM). GNF362 also inhibits Itpka and Itpkc (IC50s: 20 nM and 19 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | 5 days | $ 242.00 | |
5 mg | 5 days | $ 297.00 | |
25 mg | 6-8 weeks | $ 987.00 | |
50 mg | 6-8 weeks | $ 1,360.00 | |
100 mg | 6-8 weeks | $ 1,860.00 |
Description | GNF362 is a selective and orally bioavailable inhibitor of inositol trisphosphate 3’ kinase B (Itpkb; IC50: 9 nM). GNF362 also inhibits Itpka and Itpkc (IC50s: 20 nM and 19 nM). |
In vitro | GNF362 enhances Store-Operated Calcium (SOC) responses in primary B or T lymphocytes post-antigen receptor cross-linking, demonstrating an EC50 of 12 nM. Additionally, GNF362 (0-10 mM) inhibits Ins(1,3,4,5)P4 synthesis, bolsters calcium responses triggered by antigen receptors, and induces apoptosis in activated T cells through an Itpkb-dependent mechanism within lymphocytes. |
In vivo | GNF362 ?shows minimal block in antibody production but shows significant inhibition of joint swelling at 6 mg/kg, reduces inflammatory cell infiltrate, proteoglycan los, and sjoint damage?at 20 mg/kg. |
Molecular Weight | 426.44 |
Formula | C22H21F3N6 |
CAS No. | 1003019-41-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 125 mg/mL (293.12 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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GNF362 1003019-41-7 Others GNF 362 GNF-362 inhibitor inhibit