Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GP130 receptor agonist-1 (N-(4-Fluorophenyl)-4-phenyl-2-thiazolami) is a potent, brain-penetrant and orally active GP130 receptor agonist.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 30.00 | |
2 mg | In stock | $ 43.00 | |
5 mg | In stock | $ 68.00 | |
10 mg | In stock | $ 109.00 | |
25 mg | In stock | $ 213.00 | |
50 mg | In stock | $ 397.00 | |
100 mg | In stock | $ 575.00 | |
200 mg | In stock | $ 783.00 | |
500 mg | In stock | $ 1,180.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 96.00 |
Description | GP130 receptor agonist-1 (N-(4-Fluorophenyl)-4-phenyl-2-thiazolami) is a potent, brain-penetrant and orally active GP130 receptor agonist. |
In vitro | Compound 2 (N-(4-Fluorophenyl)-4-phenyl-2-thiazolami) treatment showed a 2-fold increase in phosphorylation of STAT3 within 10 min at its regulatory Tyr705 site in SH-SY5Y cells.. Compound 2 treatment increases phosphorylation of AKT at its regulatory Thr308 site and phosphorylation of ERK1/2 at its regulatory Thr202/Tyr204 site in the serum free media condition in SH-SY5Y cells, and in primary cortical neurons. |
In vivo | For Compound 2 (N-(4-Fluorophenyl)-4-phenyl-2-thiazolami), mice are dosed orally at 10 or 30 mg/kg, or injected subcutaneously (SQ) at 10 mg/kg, and euthanized after 1, 2, 4, 6, and 8 h post dose. At 2 h after SQ delivery at 10 mg/kg the brain Cmax is 161 ng/g while dosing at 30 mg/kg orally, results in the brain Cmax of 156 ng/g (0.57 μM). The brain to plasma ratio for 2 is ~4:1 for oral 30 mg/kg and ~7.5:1 for 10 mg/kg SQ injection. |
Synonyms | N-(4-Fluorophenyl)-4-phenyl-2-thiazolami |
Molecular Weight | 270.32 |
Formula | C15H11FN2S |
CAS No. | 339303-87-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/ml (203.46 mM)
You can also refer to dose conversion for different animals. More
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