Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GPR40/FFAR1 modulator 1 is a Gq-coupled free fatty acid receptor 1 (GPR40/FFAR1) agonist and allosteric modulator.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 45.00 | |
10 mg | In stock | $ 74.00 | |
25 mg | In stock | $ 132.00 | |
50 mg | In stock | $ 216.00 | |
100 mg | In stock | $ 349.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 84.00 |
Description | GPR40/FFAR1 modulator 1 is a Gq-coupled free fatty acid receptor 1 (GPR40/FFAR1) agonist and allosteric modulator. |
In vitro | The long-chain fatty acid receptor FFAR1/GPR40 binds agonists in both an interhelical site between the extracellular segments of transmembrane helix (TM)-III and TM-IV and a lipid-exposed groove between the intracellular segments of these helices. Molecular dynamics simulations of FFAR1 with agonist removed demonstrated a major rearrangement of the polar and charged anchor point residues for the carboxylic acid moiety of the agonist in the interhelical site, which was associated with closure of a neighboring, solvent-exposed pocket between the extracellular poles of TM-I, TM-II, and TM-VII. A synthetic compound designed to bind in this pocket, and thereby prevent its closure, was identified through structure-based virtual screening and shown to function both as an agonist and as an allosteric modulator of receptor activation[1]. |
Molecular Weight | 389.41 |
Formula | C21H19N5O3 |
CAS No. | 874755-26-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30 mg/mL (77.04 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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GPR40/FFAR1 modulator 1 874755-26-7 Endocrinology/Hormones GPCR/G Protein GPR Free Fatty Acid Receptor inhibit GPR-40/FFAR1 modulator 1 Inhibitor FFAR inhibitor