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GPR84 antagonist 8

Catalog No. T11462 CAS 1445846-30-9

GPR84 antagonist 8 is a selective GPR84 antagonist.

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GPR84 antagonist 8, CAS 1445846-30-9

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,670.00
50 mg	6-8 weeks	$ 2,180.00
100 mg	6-8 weeks	$ 2,800.00

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Biological Description

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Description

GPR84 antagonist 8 is a selective GPR84 antagonist.

In vitro

GPR84 antagonist 8 is shown to effectively counteract the decrease in cAMP production triggered by 6-OAU in GPR84-CHO cells, hinting at its ability to inhibit GPR84's action. To examine its potential in mitigating GPR84 activation's pro-inflammatory effects in macrophages, bone marrow-derived macrophages (BMDMs) pretreated with LPS were exposed to 10μM of the antagonist for 30 minutes prior to the introduction of 1μM 6-OAU. Western Blot analysis indicated that GPR84 antagonist 8 notably reduces the phosphorylation of AKT and ERK prompted by 6-OAU, showcasing its partial blockade. Given GPR84's prominence in immune cells as part of the G protein-coupled receptor family associated with metabolism, utilizing GPR84 antagonist 8 emerges as a promising anti-inflammatory approach against various inflammatory diseases. The antagonist's effectiveness and specificity were further validated through cAMP assay trials conducted on GPR84-CHO cells.

Molecular Weight	421.45
Formula	C23H23N3O5
CAS No.	1445846-30-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 5 mg/mL (11.86 mM), Sonification is recommended.

References and Literature

1. Recio C, et al. Activation of the Immune-Metabolic Receptor GPR84 Enhances Inflammation and Phagocytosis in Macrophages. Front Immunol. 2018 Jun 20;9:1419.

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Palosuran hydrochloride 540769-28-6(free base） TC-O 9311 6-OAU cangrelor tetrasodium MK-6892 ATC 0175 hydrochloride YUM70 PSN 375963

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Keywords

GPR84 antagonist 8 1445846-30-9 Endocrinology/Hormones GPCR/G Protein GPR GPR-84 antagonist 8 inhibitor inhibit

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