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GSK-3β inhibitor 2

Catalog No. T11471   CAS 1702428-31-6
Synonyms: 5-Thiazolecarboxamide,2-[2-[(cyclopropylcarbonyl)amino]-4-pyridinyl]-4-methoxy-

GSK-3β inhibitor 2 (5-Thiazolecarboxamide,2-[2-[(cyclopropylcarbonyl)amino]-4-pyridinyl]-4-methoxy-) is a BBB-crossing and selective inhibitor of GSK-3β (IC50 = 1.1 nM). GSK-3β inhibitor 2 can be used in studies about Alzheimer's disease.

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GSK-3β inhibitor 2 Chemical Structure
GSK-3β inhibitor 2, CAS 1702428-31-6
Pack Size Availability Price/USD Quantity
5 mg In stock $ 50.00
10 mg In stock $ 67.00
25 mg In stock $ 107.00
50 mg In stock $ 197.00
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Purity: 95.69%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description GSK-3β inhibitor 2 (5-Thiazolecarboxamide,2-[2-[(cyclopropylcarbonyl)amino]-4-pyridinyl]-4-methoxy-) is a BBB-crossing and selective inhibitor of GSK-3β (IC50 = 1.1 nM). GSK-3β inhibitor 2 can be used in studies about Alzheimer's disease.
Targets&IC50 GSK-3β:1.1 nM
In vitro The pyridine carboxamide of GSK-3β inhibitor 2 makes hydrogen bonds with the hinge V135 backbone amide, and the carbonyl oxygen of the thiazolyl primary amide formed a critical hydrogen bond with K85. The intramolecular hydrogen bonding between the methoxy -O- and the amide N-H in GSK-3β inhibitor 2 is confirmed by single crystal X-ray diffraction method[1].
In vivo In LaFerla 3xTg-C57BL6 mice with Alzheimer’s disease, GSK-3β inhibitor 2 (30 mg/kg; oral) significantly reduces hyperphosphorylated Tau396. GSK-3β inhibitor 2 shows only modest brain exposure (B/P = 0.26), determined as a single time point[1].
Synonyms 5-Thiazolecarboxamide,2-[2-[(cyclopropylcarbonyl)amino]-4-pyridinyl]-4-methoxy-
Molecular Weight 318.35
Formula C14H14N4O3S
CAS No. 1702428-31-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 5 mg/mL (15.71 mM), sonification is recommended.

TargetMolReferences and Literature

1. Sivaprakasam P, et al. Discovery of new acylaminopyridines as GSK-3 inhibitors by a structure guided in-depth exploration of chemical space around a pyrrolopyridinone core. Bioorg Med Chem Lett. 2015 May 1;25(9):1856-63.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compounds Library Max Antidepressant Compound Library Anti-Colorectal Cancer Compound Library Anti-Prostate Cancer Compound Library Bioactive Compound Library Metabolism Compound Library Anti-Ovarian Cancer Compound Library Neuronal Differentiation Compound Library Anti-Breast Cancer Compound Library Inhibitor Library

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Keywords

GSK-3β inhibitor 2 1702428-31-6 PI3K/Akt/mTOR signaling Stem Cells GSK-3 GSK-3b inhibitor 2 5-Thiazolecarboxamide,2-[2-[(cyclopropylcarbonyl)amino]-4-pyridinyl]-4-methoxy- GSK-3beta inhibitor 2 inhibitor inhibit

 

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