Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GSK-3β inhibitor 2 (5-Thiazolecarboxamide,2-[2-[(cyclopropylcarbonyl)amino]-4-pyridinyl]-4-methoxy-) is a BBB-crossing and selective inhibitor of GSK-3β (IC50 = 1.1 nM). GSK-3β inhibitor 2 can be used in studies about Alzheimer's disease.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 50.00 | |
10 mg | In stock | $ 67.00 | |
25 mg | In stock | $ 107.00 | |
50 mg | In stock | $ 197.00 |
Description | GSK-3β inhibitor 2 (5-Thiazolecarboxamide,2-[2-[(cyclopropylcarbonyl)amino]-4-pyridinyl]-4-methoxy-) is a BBB-crossing and selective inhibitor of GSK-3β (IC50 = 1.1 nM). GSK-3β inhibitor 2 can be used in studies about Alzheimer's disease. |
Targets&IC50 | GSK-3β:1.1 nM |
In vitro | The pyridine carboxamide of GSK-3β inhibitor 2 makes hydrogen bonds with the hinge V135 backbone amide, and the carbonyl oxygen of the thiazolyl primary amide formed a critical hydrogen bond with K85. The intramolecular hydrogen bonding between the methoxy -O- and the amide N-H in GSK-3β inhibitor 2 is confirmed by single crystal X-ray diffraction method[1]. |
In vivo | In LaFerla 3xTg-C57BL6 mice with Alzheimer’s disease, GSK-3β inhibitor 2 (30 mg/kg; oral) significantly reduces hyperphosphorylated Tau396. GSK-3β inhibitor 2 shows only modest brain exposure (B/P = 0.26), determined as a single time point[1]. |
Synonyms | 5-Thiazolecarboxamide,2-[2-[(cyclopropylcarbonyl)amino]-4-pyridinyl]-4-methoxy- |
Molecular Weight | 318.35 |
Formula | C14H14N4O3S |
CAS No. | 1702428-31-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 5 mg/mL (15.71 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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GSK-3β inhibitor 2 1702428-31-6 PI3K/Akt/mTOR signaling Stem Cells GSK-3 GSK-3b inhibitor 2 5-Thiazolecarboxamide,2-[2-[(cyclopropylcarbonyl)amino]-4-pyridinyl]-4-methoxy- GSK-3beta inhibitor 2 inhibitor inhibit