Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GSK-3β inhibitor 1 is an inhibitor of GSK-3β( IC50 of 4.9 nM) and demonstrates high antidiabetic efficacy.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 71.00 | |
5 mg | In stock | $ 166.00 | |
10 mg | In stock | $ 291.00 | |
25 mg | In stock | $ 488.00 | |
50 mg | In stock | $ 715.00 | |
100 mg | In stock | $ 987.00 |
Description | GSK-3β inhibitor 1 is an inhibitor of GSK-3β( IC50 of 4.9 nM) and demonstrates high antidiabetic efficacy. |
Targets&IC50 | GSK-3β:4.9 nM |
In vivo | GSK-3β inhibitor 1(compound 3a) inhibits GSK-3β with IC50 4.19 nM. In a cell-based assay 3a shows no significant leucocyte toxicity at 10 M and is moderately cytotoxic against A549 cells. Compound 3a demonstrated high antidiabetic efficacy in obese streptozotocin-treated rats improving glucose tolerance at a dose of 50 mg/kg body weight thus representing an interesting lead for further optimization. |
Molecular Weight | 222.24 |
Formula | C14H10N2O |
CAS No. | 187325-53-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30 mg/mL (134.99 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
GSK-3β inhibitor 1 187325-53-7 PI3K/Akt/mTOR signaling Stem Cells GSK-3 inhibit Glycogen synthase kinase 3 Glycogen synthase kinase-3 GSK3β inhibitor 1 Inhibitor GSK-3b inhibitor 1 GSK 3β inhibitor 1 GSK-3beta inhibitor 1 inhibitor