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GSK137647A

Catalog No. T3171 CAS 349085-82-1

Synonyms: GSK 137647

GSK137647A (GSK 137647) is a selective FFA4 agonist.

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GSK137647A, CAS 349085-82-1

Pack Size	Availability	Price/USD
2 mg	In stock	$ 30.00
5 mg	In stock	$ 47.00
10 mg	In stock	$ 77.00
25 mg	In stock	$ 157.00
50 mg	In stock	$ 257.00
100 mg	In stock	$ 447.00
200 mg	In stock	$ 646.00
500 mg	In stock	$ 987.00
1 mL * 10 mM (in DMSO)	In stock	$ 52.00

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Purity: 99.87%

Purity: 99.26%

Purity: 99.15%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

GSK137647A (GSK 137647) is a selective FFA4 agonist.

Kinase Assay

HDAC-inhibitory activity: For the enzyme assay, 10 μL of [3H]acetyl-labeled histones (25,000 cpm/10 μg) are added to 90 μL of the HDAC enzyme fraction extracted from 293T cells overexpressing HDAC1 or HDAC2 in the presence of increasing concentrations of Romidepsin, and the mixture is incubated at 37 °C for 15 minutes. The enzyme reaction is linear for at least 1 hour. The reaction is stopped by the addition of 10 μL of concentrated HCl. The released [3H]acetic acid is extracted with 1 mL of ethylacetate, and 0.9 mL of the solvent layer is taken into 5 mL of aqueous counting scintillant II solution for determination of radioactivity. The IC50 values are determined from at least three independent dose-response curves.

Synonyms	GSK 137647
Molecular Weight	305.39
Formula	C16H19NO3S
CAS No.	349085-82-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (163.73 mM)

H2O: < 0.06 mg/mL (insoluble or slightly soluble)

References and Literature

1. Sparks SM. Etal. Bioorg Med Chem Lett. 2014 Jul 15;24(14):3100-3.

Citations

1. Li M, Wu Y, Qiu J, et al.Huangqin Decoction ameliorates ulcerative colitis by regulating fatty acid metabolism to mediate macrophage polarization via activating FFAR4-AMPK-PPARα pathway.Journal of Ethnopharmacology.2023: 116430. 2. Zhang L, Zhang Z, Wu Y, et al.Activation of free fatty acid receptors, FFAR1 and FFAR4, ameliorates ulcerative colitis by promote fatty acid metabolism and mediate macrophage polarization.International Immunopharmacology.2024, 130: 111778.

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Bioactive Compounds Library Max NO PAINS Compound Library Target-Focused Phenotypic Screening Library Endocrinology-Hormone Compound Library Anti-Metabolism Disease Compound Library Anti-Obesity Compound Library Bioactive Compound Library

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Related compounds with same targets

Palosuran MK-7246 (1S,2R)-2-PCCA GPR4 antagonist 1 MK-6892 TUG-469 ONC212 YUM70

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

GSK137647A 349085-82-1 Endocrinology/Hormones GPCR/G Protein GPR Free Fatty Acid Receptor FFA1 FFAR insulin secretion FFA3 GSK-137647 FFA4 inhibit GSK-137647A Inhibitor GSK137647 anti-inflammatory epithelial ion transport GSK 137647 FFA2 inhibitor

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