Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GSK2256294A (GSK 2256294) is potent, selective inhibitor of recombinant human, rat and mouse sEH with IC50 of 27 pM, 61 pM and 189 pM, respectively.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 97.00 | |
5 mg | In stock | $ 217.00 | |
10 mg | In stock | $ 347.00 | |
25 mg | In stock | $ 577.00 | |
50 mg | In stock | $ 826.00 | |
100 mg | In stock | $ 1,130.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 239.00 |
Description | GSK2256294A (GSK 2256294) is potent, selective inhibitor of recombinant human, rat and mouse sEH with IC50 of 27 pM, 61 pM and 189 pM, respectively. |
Targets&IC50 | sEH:189 pM (mouse), sEH:27 pM (human), sEH:61 pM (rat) |
In vitro | GSK2256294A displays potent cellular inhibition of sEH with an IC50 of 0.66 nM in an assay developed using a cell line transfected with the human sEH enzyme[1]. |
In vivo | Mice receiving 10 days of cigarette smoke exposure concomitant with oral administration of GSK2256294A exhibits significant, dose-dependent reductions in pulmonary leukocytes and keratinocyte chemoattractant levels. Mice receiving oral administration of G |
Synonyms | GSK 2256294 |
Molecular Weight | 447.46 |
Formula | C21H24F3N7O |
CAS No. | 1142090-23-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL (100.57 mM)
You can also refer to dose conversion for different animals. More
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GSK2256294A 1142090-23-0 Metabolism Others Epoxide Hydrolase GSK-2256294A Inhibitor GSK 2256294 inhibit cigarette smoke-exposure model GSK2256294 oral COPD cardiovascular inflammation GSK-2256294 inhibitor