keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ganfeborole HCl (GSK3036656 HCl) is a small molecule compound with anti-tuberculosis activity and is an inhibitor of Mycobacterium tuberculosis (Mtb) leucyl-tRNA synthetase (LeuRS; IC50: 0.2 μM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 8-10 weeks | Inquiry | |
50 mg | 8-10 weeks | Inquiry | |
100 mg | 8-10 weeks | Inquiry |
Description | Ganfeborole HCl (GSK3036656 HCl) is a small molecule compound with anti-tuberculosis activity and is an inhibitor of Mycobacterium tuberculosis (Mtb) leucyl-tRNA synthetase (LeuRS; IC50: 0.2 μM). |
Targets&IC50 | LeuRS (Mtb):0.2 μM |
In vitro | GSK3036656 shows potent inhibition of Mtb LeuRS (IC50 = 0.20 μM) and in vitro antitubercular activity (Mtb H37Rv MIC = 0.08 μM). Additionally, it is highly selective for the Mtb LeuRS enzyme with IC50 of >300 μM and 132 μM for human mitochondrial LeuRS and human cytoplasmic LeuRS, respectively[1]. |
In vivo | GSK3036656 (0.4 mg/kg) demonstrated significant pharmacokinetic properties and efficacy against Mtb in a mouse TB infection model[1]. |
Synonyms | GSK3036656 HCl, GSK656 HCl |
Molecular Weight | 293.94 |
Formula | C10H14BCl2NO4 |
CAS No. | 2131798-13-3 |
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (170.07 mM), Sonification is recommended.
You can also refer to dose conversion for different animals. More
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Ganfeborole HCl 2131798-13-3 Microbiology/Virology Antibacterial GSK3036656 HCl GSK070 GSK-070 GSK-3036656 GSK656 GSK3036656 GSK 3036656 GSK 070 GSK656 HCl GSK-656 GSK 656 inhibitor inhibit