Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GSK840 (GSK'840) is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds the RIP3 kinase domain (IC50: 0.9 nM), and inhibits kinase activity (IC50: 0.3 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 50.00 | |
5 mg | In stock | $ 89.00 | |
10 mg | In stock | $ 126.00 | |
25 mg | In stock | $ 197.00 | |
50 mg | In stock | $ 298.00 | |
100 mg | In stock | $ 445.00 |
Description | GSK840 (GSK'840) is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds the RIP3 kinase domain (IC50: 0.9 nM), and inhibits kinase activity (IC50: 0.3 nM). |
Targets&IC50 | RIP3:0.3 nM , RIP3 kinase domain:0.9 nM |
In vitro | In human HT-29 cells, GSK840 (0.01-3 μM) blocked TNF-induced necroptosis in a concentration-dependent manner. GSK840 binded the kinase domain and inhibited kinase activity with high specificity, targeting a broader range of pro-necrotic stimuli[1]. |
Synonyms | GSK'840 |
Molecular Weight | 365.43 |
Formula | C21H23N3O3 |
CAS No. | 2361146-30-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 110 mg/mL (301.02 mM), Sonification is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
GSK840 2361146-30-5 Apoptosis NF-Κb RIP kinase GSK 840 Inhibitor GSK-840 GSK'840 Receptor-interacting protein kinases inhibit RIPK inhibitor