Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GW-311616 hydrochloride is a long duration, orally bioavailable, and selective human neutrophil elastase (HNE) inhibitor (IC50: 22 nM; Ki: 0.31 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 10-14 weeks | $ 1,350.00 | |
50 mg | 10-14 weeks | $ 1,760.00 | |
100 mg | 10-14 weeks | $ 2,670.00 |
Description | GW-311616 hydrochloride is a long duration, orally bioavailable, and selective human neutrophil elastase (HNE) inhibitor (IC50: 22 nM; Ki: 0.31 nM). |
Targets&IC50 | HNE:(ki)0.31 nM , HNE:22 nM |
In vitro | GW311616A (20-320 μM; 48 hours; U937 cells) treatment inhibits proliferation and induces apoptosis in leukemia cells. GW-311616 (150 μM; U937 cells) treatment can increase the protein expression levels of Bax and decrease the expression of Bcl-2.GW-311616 (150 μM; 48 hours) markedly suppresses NE activity in U937 and K562 cells lines. |
In vivo | GW-311616 has moderate terminal elimination half-life (t1/2) of 1.1 hours and 1.5 hours for dog (2 mg/kg, oral), rat (2 mg/kg, oral), respectively.GW-311616 (2 mg/kg;?oral administration) rapidly abolishes the circulation of neutrophil elastase (NE) in dogs, while >90% inhibition is maintained for 4 days.?This prolonged effect is independent to be due to penetration of neutrophils in bone marrow by orally administrated GW-311616. |
Synonyms | GW311616A |
Molecular Weight | 433.99 |
Formula | C19H32ClN3O4S |
CAS No. | 197890-44-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 100 mg/mL (230.42 mM)
You can also refer to dose conversion for different animals. More
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GW311616 hydrochloride 197890-44-1 Others GW311616A GW-311616 Hydrochloride GW 311616 Hydrochloride GW311616 Hydrochloride GW-311616 hydrochloride inhibitor inhibit