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Galidesivir triphosphate

Catalog No. T11352 CAS 1467740-78-8

Synonyms: BCX4430-triphosphate, Immucillin-A triphosphate, BCX6870

Galidesivir triphosphate is a substrate for viral RNA-dependent RNA polymerase (RDRP), resulting in termination of viral RNA replication and thus serves as an antiviral. Galidesivir triphosphate inhibits HCV NS5B RNA polymerase activity and protects mice against Ebola. Galidesivir triphosphate (Immucillin-A triphosphate) is converted by the prodrug Galidesivir.

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Galidesivir triphosphate Chemical Structure

Galidesivir triphosphate, CAS 1467740-78-8

Pack Size	Availability	Price/USD	Quantity
25 mg	6-8 weeks	$ 1,520.00

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Biological Description

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Description	Galidesivir triphosphate is a substrate for viral RNA-dependent RNA polymerase (RDRP), resulting in termination of viral RNA replication and thus serves as an antiviral. Galidesivir triphosphate inhibits HCV NS5B RNA polymerase activity and protects mice against Ebola. Galidesivir triphosphate (Immucillin-A triphosphate) is converted by the prodrug Galidesivir.
In vitro	Galidesivir is converted to the mono-, di-, and triphosphates in virus-infected human Huh-7 cells.?Galidesivir triphosphate (Immucillin-A triphosphate) (1-60 μM) inhibits hepatitis C virus (HCV) RNA polymerase transcriptional activity in a cell-free, isolated enzyme transcription assay.The triphosphate is a substrate for viral RNA-dependent RNA polymerase.?Its incorporation permits the addition of a few additional encoded bases at which point the Galidesivir-modified RNA cannot be elongated.In virus-infected cells, Galidesivir is converted to the triphosphate, is incorporated into the viral transcript, and functions as an atypical chain-terminator for RNA-dependent RNA polymerases.
In vivo	In vivo conversion of Galidesivir to its TP (Galidesivir triphosphate) nucleotide is particularly efficient.

Synonyms	BCX4430-triphosphate, Immucillin-A triphosphate, BCX6870
Molecular Weight	505.21
Formula	C11H18N5O12P3
CAS No.	1467740-78-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Evans GB, et al. Immucillins in Infectious Diseases. ACS Infect Dis. 2018 Feb 9;4(2):107-117. 2. Warren TK, et al. Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430. Nature. 2014 Apr 17;508(7496):402-5. 3. Taylor R, et al. BCX4430 - A broad-spectrum antiviral adenosine nucleoside analog under development for the treatment of Ebola virus disease. J Infect Public Health. 2016 May-Jun;9(3):220-6.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Galidesivir triphosphate 1467740-78-8 Others Immucillin-A Triphosphate BCX4430-triphosphate Galidesivir Triphosphate BCX 6870 Galidesivir BCX-6870 Immucillin-A triphosphate Immucillin-A BCX6870 inhibitor inhibit

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