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Galloylpaeoniflorin

Catalog No. TN1067 CAS 122965-41-7

Synonyms: 6'-O-Galloyl paeoniflorin

Galloylpaeoniflorin (6'-O-Galloyl paeoniflorin) may be developed as a cytoprotector against ROS-mediated oxidative stress. Galloylpaeoniflorin is also an inhibtior of NF-κB and DNA cleavage.

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Galloylpaeoniflorin, CAS 122965-41-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 148.00
5 mg	In stock	$ 322.00
10 mg	In stock	$ 478.00
25 mg	In stock	$ 772.00
50 mg	In stock	Inquiry
1 mL * 10 mM (in DMSO)	In stock	$ 428.00

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Description	Galloylpaeoniflorin (6'-O-Galloyl paeoniflorin) may be developed as a cytoprotector against ROS-mediated oxidative stress. Galloylpaeoniflorin is also an inhibtior of NF-κB and DNA cleavage.
In vitro	This study is the first investigation of the cytoprotective effects of GPF against hydrogen peroxide (H2O2)-induced cell injury and death in human HaCaT keratinocytes. GPF demonstrated a significant scavenging capacity against the 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical, H2O2-generated intracellular reactive oxygen species (ROS), the superoxide anion radical (O2 (-)), and the hydroxyl radical (?OH). GPF also safeguarded HaCaT keratinocytes against H2O2-provoked apoptotic cell death and attenuated oxidative macromolecular damage to DNA, lipids, and proteins. The compound exerted its cytoprotective actions in keratinocytes at least in part by decreasing the number of DNA strand breaks, the levels of 8-isoprostane (a stable end-product of lipid peroxidation), and the formation of carbonylated protein species[1]
Source	Natural Products > Paeoniaceae > Paeonia

Synonyms	6'-O-Galloyl paeoniflorin
Molecular Weight	632.57
Formula	C30H32O15
CAS No.	122965-41-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (79.04 mM)

References and Literature

1. 6'-o-galloylpaeoniflorin protects human keratinocytes against oxidative stress-induced cell damage. Biomol. Ther., 2013, 21(5):349-57.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Breast Cancer Compound Library Anti-Colorectal Cancer Traditional Chinese Medicine Compound Library Cuproptosis Compound Library Anti-Pancreatic Cancer Compound Library

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NF-κB-IN-8 Bortezomib Sulfuretin Praeruptorin A JSH-23 Eurycomalactone α-Lipoic Acid Pristimerin

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Keywords

Galloylpaeoniflorin 122965-41-7 Endocrinology/Hormones Immunology/Inflammation NF-Κb ROS Androgen Receptor NF-κB 6'-O-Galloyl paeoniflorin Nuclear factor-kappaB inhibit Inhibitor Nuclear factor-κB inhibitor

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