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Ganoderic acid H

Catalog No. TN1664 CAS 98665-19-1

Ganoderic acid H is a potent antitumour agent, it mediates its biological effects through the inhibition of transcription factors AP-1 and NF-κB, resulting in the suppression of secretion of uPA.

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Ganoderic acid H, CAS 98665-19-1

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Ganoderic acid H is a potent antitumour agent, it mediates its biological effects through the inhibition of transcription factors AP-1 and NF-κB, resulting in the suppression of secretion of uPA.

In vitro

In highly invasive human breast cancer cells, Ganoderic acid H suppressed growth (cell proliferation and colony formation) and invasive behavior (adhesion, migration and invasion) of MDA-MB-231 cells[1]. Furthermore, the activity of Ganoderic acid H is linked to the hydroxylation in the positions 7 and 3 in its triterpene lanostane structure[1]. Ganoderic acid H could be a promising natural agent for the therapy of invasive breast cancers[1].

Molecular Weight	572.695
Formula	C32H44O9
CAS No.	98665-19-1

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 80 mg/mL (139.69 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Jiang J, Grieb B, Thyagarajan A, Sliva D. Ganoderic acids suppress growth and invasive behavior of breast cancer cells by modulating AP-1 and NF-kappaB signaling. Int J Mol Med. 2008 May;21(5):577-84.

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Keywords

Ganoderic acid H 98665-19-1 DNA损伤和修复 NF-Kb信号通路细胞周期 CDK DNA/RNA Synthesis NF-κB inhibit Inhibitor inhibitor

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