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Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Gartanin is an androgen receptor degradation enhancer, it is also a potential neuroprotective agent against glutamate-induced oxidative injury partially through increasing Nrf-2-independed HO-1 and AMPK/SIRT1/PGC-1α±signaling pathways.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 162.00 | |
5 mg | In stock | $ 392.00 | |
10 mg | In stock | $ 595.00 | |
25 mg | In stock | $ 949.00 | |
50 mg | In stock | $ 1,290.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 397.00 |
Description | Gartanin is an androgen receptor degradation enhancer, it is also a potential neuroprotective agent against glutamate-induced oxidative injury partially through increasing Nrf-2-independed HO-1 and AMPK/SIRT1/PGC-1α±signaling pathways. |
In vitro | The interaction of Gartanin with the ligand-binding domain was characterized using a fluorescence polarization cell-free assay and cell-based FRET assay. Western blot analysis identified modulation of ER stress markers (BiP, PERK, IRE1, and CHOP) along with androgen receptor degradation. A computation simulation was performed to identify possible orientations of Gartanin with the ligand-binding domain. Utilizing a cell-free and cell-based FRET assays Gartanin was found to interact with the ligand-binding domain through a solely antagonist interaction. Interestingly, inhibition of CHOP, a critical component of the ER stress pathway, was observed to stabilize AR[1] |
Source |
Molecular Weight | 396.43 |
Formula | C23H24O6 |
CAS No. | 33390-42-0 |
keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (126.13 mM)
You can also refer to dose conversion for different animals. More
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