Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Gemigliptin Tartrate (LC15-0444 tartrate) is a highly selective, reversible and competitive inhibitor of dipeptidyl peptidase-4 (DPP-4). It has an IC50 of 10.3 nM for human recombinant DPP-4. Gemigliptin tartrate exhibits potent anti-glycation properties.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | In stock | $ 34.00 | |
5 mg | In stock | $ 55.00 | |
10 mg | In stock | $ 89.00 | |
25 mg | In stock | $ 159.00 | |
50 mg | In stock | $ 272.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 97.00 |
Description | Gemigliptin Tartrate (LC15-0444 tartrate) is a highly selective, reversible and competitive inhibitor of dipeptidyl peptidase-4 (DPP-4). It has an IC50 of 10.3 nM for human recombinant DPP-4. Gemigliptin tartrate exhibits potent anti-glycation properties. |
Targets&IC50 | DPP4 (human recombinant):10.3 nM |
In vitro | Gemigliptin tartrate inhibits the formation of AGE-BSA with IC50 of 11.69 mM[1]. Gemigliptin tartrate suppresses the cross-linking of preformed AGE-BSA with rat tail tendon collagen with an IC50 of 1.39 mM[1]. Gemigliptin tartrate is a competitive DPP-4 inhibitor with a Ki of 7.25 nM[2]. |
In vivo | Gemigliptin tartrate inhibits AGEs formation and AGE cross-links in vivo[1]. Gemigliptin tartrate dose-dependently inhibits plasma DPP-4 activity in rats, dogs, and monkeys[2]. |
Synonyms | LC15-0444 tartrate |
Molecular Weight | 639.45 |
Formula | C22H25F8N5O8 |
CAS No. | 1374639-74-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90 mg/mL(140.75 mM), Sonification is recommended.
You can also refer to dose conversion for different animals. More
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Gemigliptin Tartrate(911637-19-9 free base) 1374639-74-3 Proteases/Proteasome Ubiquitination Proteasome DPP-4 type Gemigliptin products mellitus peptidase-4 Gemigliptin Tartrate(911637 19 9 free base) dipeptidyl Gemigliptin Tartrate(911637199 free base) advanced diabetes Inhibitor LC15-0444 tartrate LC15-0444 Tartrate end glycation DPP Dipeptidyl Peptidase LC15-0444 AGE inhibit inhibitor