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Gentisein

Catalog No. T19931   CAS 529-49-7
Synonyms: NSC 329491, NSC329491, NSC-329491

Gentisein (NSC-329491), the major metabolite of Mangiferin, shows the most potent serotonin uptake inhibition with an IC50 value of 4.7 µM[1][2]

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Gentisein Chemical Structure
Gentisein, CAS 529-49-7
Pack Size Availability Price/USD Quantity
5 mg In stock $ 51.00
10 mg In stock $ 72.00
25 mg In stock $ 115.00
50 mg In stock $ 185.00
1 mL * 10 mM (in DMSO) In stock $ 58.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Gentisein (NSC-329491), the major metabolite of Mangiferin, shows the most potent serotonin uptake inhibition with an IC50 value of 4.7 µM[1][2]
Synonyms NSC 329491, NSC329491, NSC-329491
Molecular Weight 244.2
Formula C13H8O5
CAS No. 529-49-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 22.5 mg/mL (92.14 mM)

TargetMolReferences and Literature

1. Wang H, et al. Identification and determination of four metabolites of mangiferin in rat urine. J Pharm Biomed Anal. 2007;45(5):793-798. 2. Tzankova, Virginia et al. (2010). Inhibition of 5-HT uptake by some constituents of Hypericum annulatum in rat brain in vitro. Pharmacologyonline. 2. 3. Na Z, Xu Y. [Chemical constituents from twigs of Garcinia xipshuanbannaensis]. Zhongguo Zhong Yao Za Zhi. 2009 Sep;34(18):2338-42. Chinese. PubMed PMID: 20030083. 4. Mkounga P, Fomum ZT, Meyer M, Bodo B, Nkengfack AE. Globulixanthone F, a new polyoxygenated xanthone with an isoprenoid group and two antimicrobial biflavonoids from the stem bark of Symphonia globulifera. Nat Prod Commun. 2009 Jun;4(6):803-8. PubMed PMID: 19634326.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Neurodegenerative Disease Compound Library Tobacco Monomer Library Traditional Chinese Medicine Monomer Library Bioactive Compounds Library Max Inhibitor Library Neuronal Signaling Compound Library RO5 Drug-like Natural Product Library Polyphenolic Natural Product Library Natural Product Library for HTS Bioactive Compound Library

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Keywords

Gentisein 529-49-7 Neuroscience Serotonin Transporter 5-HT Receptor NSC 329491 Inhibitor 5-hydroxytryptamine Receptor Serotonin Receptor inhibit 1,3,7-Trihydroxyxanthone serotonin uptake antidepressant metabolite NSC329491 NSC-329491 inhibitor

 

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