Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Gomisin J is a natural product and have vasodilatory activity. Gomisin J suppresses lipid accumulation by regulating the expression of lipogenic and lipolytic enzymes and inflammatory molecules through activation of AMPK, LKB1 and Ca2+/calmodulin-dependent protein kinase II and inhibition of fetuin-A in HepG2 cells.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 39.00 | |
2 mg | In stock | $ 59.00 | |
5 mg | In stock | $ 122.00 | |
10 mg | In stock | $ 198.00 | |
25 mg | In stock | $ 347.00 | |
50 mg | In stock | $ 516.00 | |
100 mg | In stock | $ 736.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 98.00 |
Description | Gomisin J is a natural product and have vasodilatory activity. Gomisin J suppresses lipid accumulation by regulating the expression of lipogenic and lipolytic enzymes and inflammatory molecules through activation of AMPK, LKB1 and Ca2+/calmodulin-dependent protein kinase II and inhibition of fetuin-A in HepG2 cells. |
In vitro | Gomisin J attenuated lipid accumulation in OA-induced HepG2 cells.?It also suppressed the expression of lipogenic enzymes and inflammatory mediators and increased the expression of lipolytic enzymes in OA-induced HepG2 cells.?Furthermore, the use of specific inhibitors and fetuin-A siRNA and liver kinase B1 (LKB1) siRNA transfected cells demonstrated that gomisin J regulated lipogenesis and lipolysis via inhibition of fetuin-A and activation of an AMP-activated protein kinase (AMPK)-dependent pathway in HepG2 cells[1]. |
Source |
Molecular Weight | 388.45 |
Formula | C22H28O6 |
CAS No. | 66280-25-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (128.71 mM)
You can also refer to dose conversion for different animals. More
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Gomisin J 66280-25-9 Chromatin/Epigenetic Membrane transporter/Ion channel Metabolism PI3K/Akt/mTOR signaling Calcium Channel AMPK Ca channels Ca2+ channels Inhibitor AMP-activated protein kinase inhibit inhibitor