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Gossypin

Catalog No. TN1712 CAS 652-78-8

Gossypin has antidiabetic, antioxdiant, anticonvulsant, anti-allergic, antiinflammatory, antinociceptive, cytotoxic and antibacterial activities; it inhibits the NF-kappaB activation pathway, which may explain its role in the suppression of inflammation, carcinogenesis, and angiogenesis.

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Gossypin, CAS 652-78-8

Pack Size	Availability	Price/USD
10 mg	In stock	$ 139.00
25 mg	In stock	$ 222.00
50 mg	In stock	$ 333.00
1 mL * 10 mM (in DMSO)	In stock	$ 89.00

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Purity: 98.97%

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Description	Gossypin has antidiabetic, antioxdiant, anticonvulsant, anti-allergic, antiinflammatory, antinociceptive, cytotoxic and antibacterial activities; it inhibits the NF-kappaB activation pathway, which may explain its role in the suppression of inflammation, carcinogenesis, and angiogenesis.
In vitro	Gossypin is a flavone extracted from Hibiscus vitifolius, which has been reported to exhibit anti-inflammatory, antioxidant, and anticancer activities.?However, the anticancer properties of gossypin and its molecular mechanism of action against gastric cancer have not been fully investigated.?gossypin is an Aurora kinase A (AURKA) and RSK2 inhibitor that suppresses gastric cancer growth.?Gossypin attenuated anchorage-dependent and anchorage-independent gastric cancer cell growth as well as cell migration.?Based on the results of in vitro screening and cell-based assays, gossypin directly binds to and inhibits AURKA and RSK2 activities and their downstream signaling proteins.?Gossypin decreased S phase and increased G2/M phase cell cycle arrest by reducing the expression of cyclin A2 and cyclin B1 and the phosphorylation of the CDC protein.?Additionally, gossypin also induced intrinsic apoptosis by activating caspases and PARP and increasing the expression of cytochrome c. Gossypin is an AURKA and RSK2 inhibitor that could be useful for treating gastric cancer[2].
Source	Natural Products > Fabaceae > Glycyrrhiza

Molecular Weight	480.38
Formula	C21H20O13
CAS No.	652-78-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 25 mg/mL (52.04 mM)

References and Literature

1. Gossypin protects primary cultured rat cortical cells from oxidative stress- and beta-amyloid-induced toxicity.Arch Pharm Res. 2004 Apr;27(4):454-9. 2. Wang L , Wang X , Chen H , et al. Gossypin inhibits gastric cancer growth by direct targeting of AURKA and RSK2[J]. Phytotherapy Research, 2019, 33(4).

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Active Compound Library Kinase Inhibitor Library Oxidation-Reduction Compound Library Tibetan medicine Compound Library Anti-Bacterial Compound Library Stem Cell Differentiation Compound Library Glycolysis Compound Library Anti-COVID-19 Traditional Chinese Medicine Compound Library Anti-Liver Cancer Compound Library

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Keywords

Gossypin 652-78-8 MAPK NF-Κb PI3K/Akt/mTOR signaling NF-κB S6 Kinase Antiinflammatory inhibit Nuclear factor-κB Inhibitor Antioxidant Anticancer cardiovascular,osteoclastogenesis Antiallergic Nuclear factor-kappaB Antiviral Analgesic inhibitor

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