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Grp94 Inhibitor-1

Catalog No. T7261 CAS 2234897-35-7

Synonyms: HSP, Heat shock proteins, integrin αL, Inhibitor, inhibit, integrin α2, Grp-94 Inhibitor-1, Grp94 Inhibitor 1, Grp94 Inhibitor1, Grp94 Inhibitor-1, Grp94

Grp94 Inhibitor-1 is a potent, selective Grp94 inhibitor (IC50 : 2 nM).

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Grp94 Inhibitor-1, CAS 2234897-35-7

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Grp94 Inhibitor-1 is a potent, selective Grp94 inhibitor (IC50 : 2 nM).
Targets&IC50	Grp94:2 nM

Synonyms	HSP, Heat shock proteins, integrin αL, Inhibitor, inhibit, integrin α2, Grp-94 Inhibitor-1, Grp94 Inhibitor 1, Grp94 Inhibitor1, Grp94 Inhibitor-1, Grp94
Molecular Weight	352.478
Formula	C22H28N2O2
CAS No.	2234897-35-7

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 10 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Hao M, Guo Y, Zhang Z, et al. 6-acrylic phenethyl ester-2-pyranone derivative induces apoptosis and G2/ M arrest by targeting GRP94 in colorectal cancer. Bioorganic Chemistry. 2022, 123: 105802 1. Jiang F , Guo A P , Xu J C , et al. Discovery of a Potent Grp94 Selective Inhibitor with Anti-inflammatory Efficacy in a Mouse Model of Ulcerative Colitis[J]. Journal of Medicinal Chemistry, 2018.

Related compound libraries

This product is contained In the following compound libraries：

Endoplasmic Reticulum Stress Compound Library Endocrinology-Hormone Compound Library Inhibitor Library Anti-Aging Compound Library Bioactive Compound Library

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.