Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Guanfacine hydrochloride (Intuniv) is a centrally acting antihypertensive agent with specificity towards ADRENERGIC ALPHA-2 RECEPTORS.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 30.00 | |
10 mg | In stock | $ 47.00 | |
25 mg | In stock | $ 78.00 | |
50 mg | In stock | $ 140.00 | |
100 mg | In stock | $ 226.00 | |
200 mg | In stock | $ 346.00 | |
500 mg | In stock | $ 573.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 46.00 |
Description | Guanfacine hydrochloride (Intuniv) is a centrally acting antihypertensive agent with specificity towards ADRENERGIC ALPHA-2 RECEPTORS. |
Targets&IC50 | α2B-adrenoceptor:31 nM(Kd) |
Cell Research | Cells (1 mL) are seeded into 24-well plates at a density of 1 × 105 cells/mL. Culture medium is replaced every two days until cells reached confluence. To investigate the potential influence of P-gp on guanfacine transport, intracellular accumulation of guanfacine is measured in LLC-PK1/MDR1 cells and P-gp-negative LLC-PK1 cells. Rhodamine6 g, a well-known P-gp substrate, is included as a positive control. After cells reach confluence, the culture medium is replaced by transport buffer for a 30-minute preincubation at 37°C. Transport buffer is then removed and the test compounds (5 μM rhodamine6 g, 5 μM guanfacine, or 50 μM guanfacine) are added, and an additional 60-minute incubation period commenced. Next, the solutions are discarded, and the cells are washed three times with ice-cold Dulbecco's phosphate-buffered saline and solubilized with 1% Triton X-100. Intracellular accumulation of rhodamine6 g is measured using a fluorescent microplate reader with a 530 nm excitation and a 580 nm emission wavelength, which is a well established method. Cellular retention of guanfacine is analyzed by the high-performance liquid chromatographic assay described below. The concentrations of rhodamine6 g and guanfacine are calculated from their respective standard curves, and standardized with the cellular protein content determined by a Pierce bicinchoninic acid protein kit.(Only for Reference) |
Synonyms | Tenex, Intuniv, Guanfacine |
Molecular Weight | 282.55 |
Formula | C9H10Cl3N3O |
CAS No. | 29110-48-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 28.3 mg/mL (100 mM)
H2O: 28.3 mg/mL (100 mM)
You can also refer to dose conversion for different animals. More
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Guanfacine hydrochloride 29110-48-3 GPCR/G Protein Neuroscience Adrenergic Receptor hypotension Inhibitor inhibit noradrenergic α2A tourette's syndrome sedation attention deficit hyperactivity disorder (ADHD) Guanfacine Hydrochloride Tenex α2A receptor Intuniv cognitive disorders Guanfacine prefrontal cortex (PFC) Beta Receptor inhibitor