store at low temperture,keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release. It also inhibit non-small cell lung carcinoma A549 cell inhibitory activity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 128.00 | |
5 mg | In stock | $ 312.00 | |
10 mg | In stock | $ 397.00 |
Description | Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release. It also inhibit non-small cell lung carcinoma A549 cell inhibitory activity. |
In vitro | gypenoside L (Gyp-L), a saponin isolated from Gynostemma pentaphyllum, on cancer cell growth.?We found that Gyp-L increased the SA-β-galactosidase activity, promoted the production of senescence-associated secretory cytokines, and inhibited cell proliferation of human liver and esophageal cancer cells.?Moreover, Gyp-L caused cell cycle arrest at S phase, and activated senescence-related cell cycle inhibitor proteins (p21 and p27) and their upstream regulators.?In addition, Gyp-L activated p38 and ERK MAPK pathways and NF-κB pathway to induce senescence.?Consistently, adding chemical inhibitors efficiently counteracted the Gyp-L-mediated senescence, growth inhibition, and cell cycle arrest in cancer cells.?Furthermore, treatment with Gyp-L, enhanced the cytotoxicity of clinic therapeutic drugs, including 5-fluorouracil and cisplatin, on cancer cells.?Overall, these results indicate that Gyp-L inhibits proliferation of cancer cells by inducing senescence and renders cancer cells more sensitive to chemotherapy[1]. |
Source |
Molecular Weight | 801.01 |
Formula | C42H72O14 |
CAS No. | 94987-09-4 |
store at low temperture,keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 166.67 mg/mL (208.07 mM), sonification is recommended.
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Gypenoside L 94987-09-4 Immunology/Inflammation MAPK Membrane transporter/Ion channel Metabolism NF-Κb ROS ERK p38 MAPK Calcium Channel NF-κB Extracellular signal regulated kinases Nuclear factor-κB saponin anti-tumor Nuclear factor-kappaB inhibit anti-inflammatory Inhibitor cytokines p38 inhibitor