Home Tools
Log in
Cart

Gypenoside L

Catalog No. TN1721   CAS 94987-09-4

Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release. It also inhibit non-small cell lung carcinoma A549 cell inhibitory activity.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Gypenoside L Chemical Structure
Gypenoside L, CAS 94987-09-4
Pack Size Availability Price/USD Quantity
1 mg In stock $ 128.00
5 mg In stock $ 312.00
10 mg In stock $ 397.00
Bulk Inquiry
Get quote
Select Batch  
Purity: 99.65%
Purity: 99.42%
Contact us for more batch information
Biological Description
Chemical Properties
Storage & Solubility Information
Description Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release. It also inhibit non-small cell lung carcinoma A549 cell inhibitory activity.
In vitro gypenoside L (Gyp-L), a saponin isolated from Gynostemma pentaphyllum, on cancer cell growth.?We found that Gyp-L increased the SA-β-galactosidase activity, promoted the production of senescence-associated secretory cytokines, and inhibited cell proliferation of human liver and esophageal cancer cells.?Moreover, Gyp-L caused cell cycle arrest at S phase, and activated senescence-related cell cycle inhibitor proteins (p21 and p27) and their upstream regulators.?In addition, Gyp-L activated p38 and ERK MAPK pathways and NF-κB pathway to induce senescence.?Consistently, adding chemical inhibitors efficiently counteracted the Gyp-L-mediated senescence, growth inhibition, and cell cycle arrest in cancer cells.?Furthermore, treatment with Gyp-L, enhanced the cytotoxicity of clinic therapeutic drugs, including 5-fluorouracil and cisplatin, on cancer cells.?Overall, these results indicate that Gyp-L inhibits proliferation of cancer cells by inducing senescence and renders cancer cells more sensitive to chemotherapy[1].
Source
Molecular Weight 801.01
Formula C42H72O14
CAS No. 94987-09-4

Storage

store at low temperture,keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 166.67 mg/mL (208.07 mM), sonification is recommended.

TargetMolReferences and Literature

1. Jingxin Ma , Xiaopeng Hu , Chenghui Liao,et al. Gypenoside L Inhibits Proliferation of Liver and Esophageal Cancer Cells by Inducing Senescence.[J]. Molecules (Basel, Switzerland), 2019. 2. Dammarane-type saponins from heat-processed Gynostemma pentaphyllum show fortified activity against A549 cells. Archives of Pharmacal Research, 2013, 36(7):874-879.

Related compound libraries

This product is contained In the following compound libraries:
Ferroptosis Compound Library Anti-Colorectal Cancer Traditional Chinese Medicine Compound Library Cuproptosis Compound Library NO PAINS Compound Library MAPK Inhibitor Library Calcium Antagonist Library Rare Natural Compound Library

Related Products

Related compounds with same targets
2-Hydroxy-3-methylanthraquinone Torilin A-674563 EF24 β,β-Dimethylacrylshikonin Rupestonic acid Licochalcone D ERK2 IN-1

TargetMolDose Conversion

You can also refer to dose conversion for different animals. More

TargetMol In vivo Formulation Calculator (Clear solution)

Step One: Enter information below
Dosage
mg/kg
Average weight of animals
g
Dosing volume per animal
ul
Number of animals
Step Two: Enter the in vivo formulation
% DMSO
%
% Tween 80
% ddH2O
Calculate Reset

TargetMolCalculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculation
Molecular Weight Calculator
=
X
X

Molarity Calculator allows you to calculate the

  • Mass of a compound required to prepare a solution of known volume and concentration
  • Volume of solution required to dissolve a compound of known mass to a desired concentration
  • Concentration of a solution resulting from a known mass of compound in a specific volume
See Example

An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
Enter 10 into the Volume box and select the correct unit (milliliter)
Press calculate
The answer of 19.713 mg appears in the Mass box

X
=
X

Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

See Example

An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
Enter 20 into the Volume (final) box and select the correct unit (milliliter)
Press calculate
The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

=
/

Calculate the volume of solvent required to reconstitute your vial.

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial.
Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

g/mol

Enter the chemical formula of a compound to calculate its molar mass and elemental composition

Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

bottom

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Gypenoside L 94987-09-4 Immunology/Inflammation MAPK Membrane transporter/Ion channel Metabolism NF-Κb ROS ERK p38 MAPK Calcium Channel NF-κB Extracellular signal regulated kinases Nuclear factor-κB saponin anti-tumor Nuclear factor-kappaB inhibit anti-inflammatory Inhibitor cytokines p38 inhibitor

 

TargetMol