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H-Tyr(3-I)-OH

Catalog No. T5568 CAS 70-78-0

Synonyms: 3-Iodo-L-tyrosine

H-Tyr(3-I)-OH (3-Iodo-L-tyrosine) is an inhibitor of tyrosine hydroxylase (Ki = 0.39 M) and an intermediate in the synthesis of thyroid hormones

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H-Tyr(3-I)-OH, CAS 70-78-0

Pack Size	Availability	Price/USD
25 mg	In stock	$ 30.00
50 mg	In stock	$ 39.00
100 mg	In stock	$ 55.00
500 mg	In stock	$ 133.00

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Purity: 99.73%

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Description	H-Tyr(3-I)-OH (3-Iodo-L-tyrosine) is an inhibitor of tyrosine hydroxylase (Ki = 0.39 M) and an intermediate in the synthesis of thyroid hormones
In vivo	3-iodo-L-tyrosine, at high concentration, is able to induce the intracellular aggregation of αSyn, and death of TH-positive neurons. These phenomena are considered as hallmarks of PD
Animal Research	Twenty mice were infused with H-Tyr(3-I)-OH into the dorsal striata.?Mice were anesthetized with ketamine (50 mg/kg IP) and xylazine (5mg/kg IP,) and placed in a David Kopf stereotaxic apparatus.?Vehicle and H-Tyr(3-I)-OH solution (0, 1 and 10μM H-Tyr(3-I)-OH dissolved in 0.9% NaCl with 0.001% acetic acid) was slowly injected (5 μl volume) with a blunted 30-gauge cannula at the following coordinates of the left dorsal striata with respect to bregma: AP= +0.86, L= +1.6, and V= -3.5 mm.

Synonyms	3-Iodo-L-tyrosine
Molecular Weight	307.09
Formula	C9H10INO3
CAS No.	70-78-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 10 mM

DMSO: Insoluble

References and Literature

1. Fernández-Espejo Emilio, Cristian B H . Excess amounts of 3-iodo-L-tyrosine induce Parkinson-like features in experimental approaches of Parkinsonism[J]. NeuroToxicology, 2018:S0161813X18301980-.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Human Endogenous Metabolite Library RO5 Drug-like Natural Product Library Bioactive Compounds Library Max Natural Product Library Natural Product Library for HTS Human Endogenous Metabolite Compound Library Plus Human Metabolite Library NO PAINS Compound Library Bioactive Compound Library

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Keywords

H-Tyr(3-I)-OH 70-78-0 Metabolism Endogenous Metabolite thyroid hormone inhibit H Tyr(3 I) OH metabolite tyrosine hydroxylase HTyr(3I)OH Inhibitor 3-Iodo-L-tyrosine inhibitor

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