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HDAC8-IN-1

Catalog No. T7082 CAS 1417997-93-3

MDK-7933 (HDAC8-IN-1) is a HDAC8 inhibitor with an IC50 of 27.2 nM in cancer cell lines. MDK-7933 shows antiproliferative effects toward several human lung cancer cell lines (A549, H1299, and CL1-5). HDAC8-IN-1 exhibits cytotoxicity against human lung CL1-5 cells without significant cytotoxicity for normal IMR-90 cells[1].

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HDAC8-IN-1, CAS 1417997-93-3

Pack Size	Availability	Price/USD
2 mg	In stock	$ 66.00
5 mg	In stock	$ 101.00
10 mg	In stock	$ 154.00
25 mg	In stock	$ 309.00
50 mg	In stock	$ 479.00
100 mg	In stock	$ 611.00
1 mL * 10 mM (in DMSO)	In stock	$ 112.00

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Purity: 99.83%

Purity: 99.19%

Purity: 97.13%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	MDK-7933 (HDAC8-IN-1) is a HDAC8 inhibitor with an IC50 of 27.2 nM in cancer cell lines. MDK-7933 shows antiproliferative effects toward several human lung cancer cell lines (A549, H1299, and CL1-5). HDAC8-IN-1 exhibits cytotoxicity against human lung CL1-5 cells without significant cytotoxicity for normal IMR-90 cells[1].
Targets&IC50	HDAC8:27.2 nM

Molecular Weight	345.39
Formula	C22H19NO3
CAS No.	1417997-93-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 130 mg/mL

References and Literature

1. Huang WJ, et al. Synthesis and biological evaluation of ortho-aryl N-hydroxycinnamides as potent histone deacetylase (HDAC) 8 isoform-selective inhibitors. ChemMedChem. 2012 Oct;7(10):1815-24.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Active Compound Library Bioactive Compounds Library Max NF-κB Signaling Compound Library Chromatin Modification Compound Library Anti-Lung Cancer Compound Library DNA Damage & Repair Compound Library Anti-Aging Compound Library Anti-Breast Cancer Compound Library Anti-Pancreatic Cancer Compound Library

Related Products

Related compounds with same targets

BML-210 AR42 Nexturastat A Entinostat SP-2-225 HPOB HDAC1/CDK7-IN-1 HFY-4A

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

HDAC8-IN-1 1417997-93-3 Chromatin/Epigenetic DNA Damage/DNA Repair HDAC HDAC-8-IN-1 HDAC8IN1 Histone deacetylases Inhibitor inhibit HDAC8 IN 1 inhibitor

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