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HPI 1

Catalog No. T22089 CAS 599150-20-6

HPI 1 is a hedgehog (Hh) signaling inhibitor. Inhibits Sonic hedgehog (Shh)-, SAG- and Gli-induced Hh pathway activation in Shh-LIGHT2 cells (IC50 values are 1.5, 1.5, 4, and 6 μM for Shh-, SAG-, Gli2- and Gli1-induced activation).

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HPI 1, CAS 599150-20-6

Pack Size	Availability	Price/USD
1 mg	In stock	$ 39.00
2 mg	In stock	$ 55.00
5 mg	In stock	$ 93.00
10 mg	In stock	$ 137.00
25 mg	In stock	$ 229.00
50 mg	In stock	$ 342.00
100 mg	In stock	$ 497.00
500 mg	In stock	$ 1,080.00
1 mL * 10 mM (in DMSO)	In stock	$ 109.00

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Purity: 94.4%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	HPI 1 is a hedgehog (Hh) signaling inhibitor. Inhibits Sonic hedgehog (Shh)-, SAG- and Gli-induced Hh pathway activation in Shh-LIGHT2 cells (IC50 values are 1.5, 1.5, 4, and 6 μM for Shh-, SAG-, Gli2- and Gli1-induced activation).
Targets&IC50	SAG:1.5μM, Shh:1.5μM, GLI2:4μM

Molecular Weight	463.52
Formula	C27H29NO6
CAS No.	599150-20-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 65 mg/ml (140.23 mM)

References and Literature

1. Gavrish E, et al. In vitro and in vivo activities of HPi1, a selective antimicrobial against Helicobacter pylori. Antimicrob Agents Chemother. 2014 Jun;58(6):3255-60.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library GPCR Compound Library Anti-Prostate Cancer Compound Library Osteogenesis Compound Library NO PAINS Compound Library Reprogramming Compound Library Bioactive Compound Library Bioactive Compounds Library Max Stem Cell Differentiation Compound Library Anti-Cancer Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

HPI 1 599150-20-6 GPCR/G Protein Stem Cells Hedgehog/Smoothened SUM149 anti-proliferative inhibit colony formation HPI-1 Gli GLI1 mRNA HPI1 SUM159 cells GLI antagonist1 GLI antagonist-1 Inhibitor GLI antagonist 1 inhibitor

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